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Table 2 Differential PRF1 enhancer methylation according to clinical features of RSV bronchiolitis among cases only

From: Reduced PRF1 enhancer methylation in children with a history of severe RSV bronchiolitis in infancy: an association study

Characteristics

DNA methylation levels at the PRF1 enhancer

 

CpG E1

 

CpG E2

 
 

n

median (p25, p75) or Spearman’s coefficient

p-value*

n

median (p25, p75) or Spearman’s coefficient

p-value*

Age at hospitalisation (years)

38

−014

0.42

38

−016

0.33

Age at blood sampling

43

0.08

0.61

43

0.10

0.54

Gender

  

0.79

  

0.30

Female

15

68.0 (62.5, 73.5)

 

15

67.0 (63.0, 70.0)

 

Male

28

69.5 (61.0, 74.5)

 

28

64.8 (59.3, 70.0)

 

Gestational age

  

0.32

  

0.98

≥37 weeks

30

68.3 (63.0, 73.5)

 

30

64.8 (62.0, 68.5)

 

<37 weeks

7

62.0 (36.0, 73.5)

 

7

65.5 (36.0, 72.0)

 

Sibling status

  

0.62

  

0.57

None

2

55.3 (36.0, 74.5)

 

2

53.0 36.0, 70.0)

 

≥1

33

69.5 (63.0, 74.5)

 

33

65.5 (63.0, 71.5)

 

Smoking in the household

  

0.08

  

0.14

No

19

72.0 (66.0, 74.0)

 

19

67.0 (63.5, 72.0)

 

Yes

21

65.5 (61.0, 70.0)

 

21

64.0 (61.5, 68.5)

 

Previous wheeze

  

0.04

  

0.13

No

36

69.5 (63.8, 74.5)

 

36

65.5 (62.5, 71.0)

 

Yes

4

62.3 (43.5, 64.3)

 

4

63.3 (42.0, 64.5)

 

Parent allergic disease

  

0.50

  

0.23

No

20

69.5 (63.0, 75.0)

 

20

67.0 (63.5, 71.8)

 

Yes

20

68.8 (62.3, 72.8)

 

20

64.0 (61.8, 69.3)

 

Paternal asthma

  

0.07

  

0.19

No

37

69.5 (63.0, 74.5)

 

37

65.0 (63.0, 70.5)

 

Yes

3

62.0 (25.0, 66.0)

 

3

63.5 (21.0, 65.5)

 

Maternal asthma

  

0.32

  

0.04

No

37

69.5 (63.0, 74.5)

 

37

65.5 (63.0, 70.5)

 

Yes

3

66.0 (25.0, 70.0)

 

3

61.5 (21.0, 63.5)

 

Days of oxygen supplementation

40

−0.05

0.74

40

−0.11

0.51

Antibiotic therapy

  

0.62

  

0.65

No

12

69.5 (46.8, 74.5)

 

12

65.0 (46.5, 71.8)

 

Yes

28

69.5 (63.8, 74.0)

 

28

65.0 (63.5, 69.5)

 

Corticosteroid therapy

  

0.38

  

0.32

No

28

67.8 (61.8, 74.0)

 

28

64.8 (61.5, 70.3)

 

Yes

12

71.3 (65.0, 74.0)

 

12

66.5 (64.0, 71.0)

 
  1. Differences in the total number of observations are due to missing data
  2. n number of observations, p25 25th percentile, p75 75th percentile
  3. *p-value for categorical variables calculated using Kruskal-Wallis test