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Table 3 Kaplan-Meier (unadjusted) and Cox proportional regression (adjusted) analyses for age at attainment of milestones for HIV-infected infants stratified by ART responses and ART regimen and compared with HIV-unexposed uninfected infants

From: Comparison of developmental milestone attainment in early treated HIV-infected infants versus HIV-unexposed infants: a prospective cohort study

  Unadjusted b Adjusted c
  Na Median (IQR) Months P HR (95% CI) P
Walking unsupported
 HUU-reference 69 13 (11, 14)    
 HIV+, 6-mo VL <1000 c/mL 28 15 (13, 16) 0.0009 0.58 (0.36, 0.92) 0.02*
 HIV+, 6-mo VL ≥1000 c/mL 25 16 (13, 20) 0.0001 0.43 (0.24, 0.76) 0.004
 HIV+, 6-mo CD4% ≥25% 27 14 (13, 15) 0.02 0.73 (0.46, 1.16) 0.2*
 HIV+, 6-mo CD4% <25% 27 17 (13, 20) <0.0001 0.35 (0.19, 0.61) <0.001
 HIV+, 6-mo WAZ ≥ −2 38 15 (13, 16) 0.001 0.59 (0.39, 0.90) 0.014*
 HIV+, 6-mo WAZ < −2 15 17 (13, 22) <0.0001 0.26 (0.13, 0.53) <0.001
Monosyllabic speech
 HUU-reference 72 12 (10, 13)   - -
 HIV+, 6-mo VL <1000 c/mL 28 15 (12, 16) <0.0001 0.28 (0.16, 0.46) <0.001*
 HIV+, 6-mo VL ≥1000 c/mL 24 15 (14, 19) <0.0001 0.20 (0.11, 0.36) <0.001
 HIV+, 6-mo CD4% ≥25% 27 14 (12, 16) <0.0001 0.33 (0.21, 0.55) <0.001*
 HIV+, 6-mo CD4% <25% 26 16 (14, 19) <0.0001 0.14 (0.08, 0.27) <0.001
 HIV+, 6-mo WAZ ≥ −2 37 14 (13, 16) <0.0001 0.26 (0.16, 0.42) <0.001*
 HIV+, 6-mo WAZ < −2 15 16 (15, 19) <0.0001 0.15 (0.07, 0.29) <0.001
  1. HUU HIV-unexposed uninfected, HIV+  HIV-infected, IQR interquartile range, CI confidence interval, VL plasma viral load (HIV RNA), WAZ weight - for - age Z-score
  2. aN, number of events
  3. b Comparison of each group of HIV-infected infants vs HIV-unexposed uninfected infants (HUU) using log - rank tests
  4. c Cox regression analyses adjusted for monthly household rent. For comparisons of effective viral load and CD4%, adjustment was also made for WAZ < −2 at 9 months of age (approximately 6 months after initiating ART)
  5. *Using Bonferroni to account for 6 multiple comparisons, P-values <0.008 were considered statistically significant