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Table 2 Median 17-OHP levels in infants with suspected congenital adrenal hyperplasia on newborn screening and retest according to birth weight tier

From: Neonatal screening for congenital adrenal hyperplasia in Southern Brazil: a population based study with 108,409 infants

Sample#

Birth weight tier

p

≤1500 g

n = 23

1501–2000 g

n = 67

2001–2500 g

n = 105

≥2501 g

n = 298 §

Screening (median ng/mL [P25-75])

154 (120 to 208)a

53.6 (47.0 to 64.7)b

33.6 (29.9 to 41.9)c

18.8 (16.0 to 23.4)d

<0.001

Retest (median ng/mL [P25-75])

48.1 (21.9 to 96.5)a

12.7 (10.1 to 20.5)b

8.1 (6.4 to 12.3)c

7.3 (5.1 to 10.6)d

<0.001

∆ Samples

−98.6 (−172.5 to −67.0)a

−38.9 (−47.2 to −33.2)b

−24.9 (−31.5 to −21.2)c

−11.8 (−15.6 to −7.95)d

<0.001

  1. #17-OHP diagnostic cut-off levels: birth weight ≤ 1500 g: 110.4 ng/mL; birth weight 1501 to 2000 g: 43 ng/mL; birth weight 2001 to 2500 g: 28.2 ng/mL; and birth weight weight > 2500 g: 15.1 ng/mL; § n = 297 on retest
  2. ∆ Samples: difference between 17-OHP at retest and screening
  3. Values are expressed as median and interquartile range; different superscript letters indicate statistical difference by GEE test