Table 2 Lung function testing of infants treated with and without PDA ligation
N | hsPDA successfully treated with COX inhibitors | PDA ligation after unsuccessful treatment with COX inhibitors | p-value | |
|---|---|---|---|---|
Tidal breathing | ||||
VT (mL/kg) | 107 | 5.96 (5.27 – 6.39) | 5.15 (4.35 – 6.10) | 0.007 |
RR (1/min) | 107 | 40.0 (36.0 – 47.0) | 43.5 (36.0 – 47.0) | 0.132 |
V’E (mL/min/kg) | 107 | 234.2 (207.3 – 274.3) | 221.6 (186.6 – 252.0) | 0.137 |
PTIF (L/min/kg) | 107 | 0.85 (0.77 – 1.0) | 0.87 (0.71 – 0.98) | 0.984 |
PTEF (L/min/kg) | 107 | 0.77 (0.64 – 0.96) | 0.71 (0.58 – 0.88) | 0.078 |
tptef/te (%) | 107 | 18.1 (14.1 – 24.5) | 17.2 (15.4 – 23.3) | 0.896 |
Forced expiratory flow | ||||
V’max FRC (mL/s) | 95 | 42.0 (25.0 – 61.0) | 31.0 (13.0 – 52.0) | 0.019 |
Z-Score V’maxFRC | 95 | −1.82 (−2.48 – −1.07) | −2.53 (−3.0 – −1.74) | 0.006 |
Respiratory Mechanics | ||||
Crs (mL/kPa/kg) | 114 | 9.6 (8.1 – 10.6) | 7.2 (6.3 – 9.1) | <0.001 |
Rrs (kPa/L/s) | 114 | 6.6 (5.2 – 8.3) | 7.5 (6.3 – 8.3) | 0.076 |
Raw (kPa/L/s) | 114 | 2.84 (1.70 – 4.19) | 4.81 (3.64 – 6.14) | <0.001 |
Lung volumes and lung clearing index | ||||
FRCPleth (mL/kg) | 114 | 20.9 (18.8 – 24.2) | 21.1 (18.0 – 23.9) | 0.852 |
FRCSF6 (mL/kg) | 76 | 19.7 (15.6 – 24.3) | 22.4 (18.6 – 25.2) | 0.168 |
LCI | 76 | 6.0 (5.5 – 6.8) | 6.0 (5.7 – 6.9) | 0.601 |
Exhalation gas analysis | ||||
eNO (ppb) | 45 | 9.0 (3.3 – 18.2) | 7.9 (3.7 – 11.3) | 0.851 |
V’NO (nL/s) | 45 | 11.8 (3.8 – 26.4) | 14.4 (7.3 – 26.4) | 0.617 |
Blood gas analysis | ||||
paO2 (mmHg) | 113 | 70.6 (60.7 – 80.7) | 59.7 (50.8 – 70.9) | <0.001 |
paCO2 (mmHg) | 113 | 40.9 (38.1 – 44.3) | 45.1 (42.0 – 52.2) | <0.001 |