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Table 4 Changes from baseline in prolactin

From: Prolactin-related adverse events and change in prolactin levels in pediatric patients given antipsychotics for schizophrenia and schizophrenia spectrum disorders: A systematic review

Study Treatment Time point, weeks Prolactin change, both sexes (ng/mL), mean (SD) Prolactin change, males (ng/mL), mean (SD) Prolactin change, females (ng/mL), mean (SD)
Randomized controlled trials
Findling et al. 2012 [21] Quetiapine 400 mg/day 6 −10.6 (16.1) −9.22 (14.4) −12.4 (18.5)
Quetiapine 800 mg/day 6 −7.8 (26.5) −3.7 (11.6) −14.0 (39.1)
Placebo 6 −18.3 (28.8) −6.53 (15.1) −33.9 (34.9)
Findling et al. 2008 [22] Aripiprazole 10 mg/day 6 −11.9 (23.3) NR NR
Aripiprazole 30 mg/day 6 −15.1 (26.9) NR NR
Placebo 6 −8.5 (24.2) NR NR
Haas et al. 2009a [23] Risperidone 1–3 mg/day 6 25.5 (33.5) 16 (23.7) 36.9 (41.3)
Risperidone 4–6 mg/day 6 49.5 (46.9) 26.4 (28.5) 77.3 (60.8)
Placebo 6 −5.9 (24.9) −3.2 (24.8) −9.2 (24.1)
Haas et al. 2009b [26] Risperidone 1.5–6 mg/day 8 NR NR NR
Risperidone 0.15–0.6 mg/day 8 NR NR NR
Kryzhanovskaya et al. 2009 [24] Olanzapine 2.5–20 mg/day 6 8.8 (17.9) NR NR
Placebo 6 −3.3 (14.8) NR NR
Singh et al. 2011 [25] Paliperidone 1.5 mg/day 6 3.3 (36.0) 3.6 (19.1) 2.9 (48.6)
Paliperidone 3–6 mg/day 6 22.7 (34.1) 22.8 (30.1) 22.4 (38.7)
Paliperidone 6–12 mg/day 6 22.4 (35.5) 21.3 (31.1) 24.9 (42.0)
Placebo 6 2.7 (15.2) 0.6 (9.4) 4.4 (18.3)
Observational studies
Duval et al. 2008 [27] Risperidone 1–6 mg/day 3 47.9 (23.6) NR NR
Kumra et al. 2008 [28] Clozapine 25–900 mg/day 12 NR NR NR
Olanzapine 30 mg/day 12 NR NR NR
Clozapine 25–900 mg/day 24 NR NR NR
Olanzapine 30 mg/day 24 NR NR NR
Pandina et al. 2012 [29] Risperidone 2–6 mg/day (treatment-naïve) 24 66.8 (41.8) 29.1 (32.6) 83.4 (44.7)
Risperidone 2–6 mg/day (treatment-experienced) 24 −11.6 (43.3) −6.2 (22.2) −14.0 (49.3)
Risperidone 2–6 mg/day (open-label) 48 6.8 (35.2) 3.7 (28.5) 11.5 (43.3)
Ruan et al. 2010 [30] Risperidone 25–50 mg biweekly 24 −13.1 (17.1) NR NR
Schimmelmann et al. 2007 [31] Quetiapine 200–800 mg/day 12 −1.4 (21.1) −4.5 (5.7) 3.2 (21.7)
  1. NR Not reported, SD Standard deviation
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