Table 4 Changes from baseline in prolactin

Findling et al. 2012 [21]

Quetiapine 400 mg/day

6

−10.6 (16.1)

−9.22 (14.4)

−12.4 (18.5)

Quetiapine 800 mg/day

6

−7.8 (26.5)

−3.7 (11.6)

−14.0 (39.1)

Placebo

6

−18.3 (28.8)

−6.53 (15.1)

−33.9 (34.9)

Findling et al. 2008 [22]

Aripiprazole 10 mg/day

6

−11.9 (23.3)

NR

NR

Aripiprazole 30 mg/day

6

−15.1 (26.9)

NR

NR

Placebo

6

−8.5 (24.2)

NR

NR

Haas et al. 2009a [23]

Risperidone 1–3 mg/day

6

25.5 (33.5)

16 (23.7)

36.9 (41.3)

Risperidone 4–6 mg/day

6

49.5 (46.9)

26.4 (28.5)

77.3 (60.8)

Placebo

6

−5.9 (24.9)

−3.2 (24.8)

−9.2 (24.1)

Haas et al. 2009b [26]

Risperidone 1.5–6 mg/day

8

NR

NR

NR

Risperidone 0.15–0.6 mg/day

8

NR

NR

NR

Kryzhanovskaya et al. 2009 [24]

Olanzapine 2.5–20 mg/day

6

8.8 (17.9)

NR

NR

Placebo

6

−3.3 (14.8)

NR

NR

Singh et al. 2011 [25]

Paliperidone 1.5 mg/day

6

3.3 (36.0)

3.6 (19.1)

2.9 (48.6)

Paliperidone 3–6 mg/day

6

22.7 (34.1)

22.8 (30.1)

22.4 (38.7)

Paliperidone 6–12 mg/day

6

22.4 (35.5)

21.3 (31.1)

24.9 (42.0)

Placebo

6

2.7 (15.2)

0.6 (9.4)

4.4 (18.3)

Duval et al. 2008 [27]

Risperidone 1–6 mg/day

3

47.9 (23.6)

NR

NR

Kumra et al. 2008 [28]

Clozapine 25–900 mg/day

12

NR

NR

NR

Olanzapine 30 mg/day

12

NR

NR

NR

Clozapine 25–900 mg/day

24

NR

NR

NR

Olanzapine 30 mg/day

24

NR

NR

NR

Pandina et al. 2012 [29]

Risperidone 2–6 mg/day (treatment-naïve)

24

66.8 (41.8)

29.1 (32.6)

83.4 (44.7)

Risperidone 2–6 mg/day (treatment-experienced)

24

−11.6 (43.3)

−6.2 (22.2)

−14.0 (49.3)

Risperidone 2–6 mg/day (open-label)

48

6.8 (35.2)

3.7 (28.5)

11.5 (43.3)

Ruan et al. 2010 [30]

Risperidone 25–50 mg biweekly

24

−13.1 (17.1)

NR

NR

Schimmelmann et al. 2007 [31]

Quetiapine 200–800 mg/day

12

−1.4 (21.1)

−4.5 (5.7)

3.2 (21.7)