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Table 1 Characteristics of included studies

From: Prolactin-related adverse events and change in prolactin levels in pediatric patients given antipsychotics for schizophrenia and schizophrenia spectrum disorders: A systematic review

Study Diagnosis (criteria for diagnosis) Treatment(s) Treatment duration, weeks Inclusion criteria
Randomized controlled trials
Findling et al. 2012 [21] Schizophrenia (DSM-IV-TR + K-SADS-PL) Quetiapine 400 mg/day
Quetiapine 800 mg/day
Placebo
6 Inpatients or outpatients aged 13–17 years; PANSS ≥ 60
Findling et al. 2008 [22] Schizophrenia (DSM-IV) Aripiprazole 10 mg/day
Aripiprazole 30 mg/day
Placebo
6 Aged 13–17 years; PANSS ≥ 70
Haas et al. 2009a [23] Schizophrenia (DSM-IV + K-SADS-PL) Risperidone 1–3 mg/day
Risperidone 4–6 mg/day
Placebo
6 Aged 13–17 years; PANSS 60–120
Haas et al. 2009b [26] Schizophrenia (DSM-IV + K-SADS-PL) Risperidone 1.5–6 mg/day
Risperidone 0.15–0.6 mg/day
8 Aged 13–17 years; PANSS 60–120
Kryzhanovskaya et al. 2009 [24] Schizophrenia (DSM-IV-TR) Olanzapine 2.5–20 mg/day
Placebo
6 Aged 13–17 years; BPRS ≥ 35
Singh et al. 2011 [25] Schizophrenia (DSM-IV + K-SADS-PL) Paliperidone 1.5 mg/day
Paliperidone 3–6 mg/day
Paliperidone 6–12 mg/day
Placebo
6 Aged 12–17 years; Weight ≥ 29 kg; PANSS 60–120
Observational studies
Duval et al. 2008 [27] Schizophreniform disorder (DSM-IV) Risperidone 1–6 mg/day 3 Aged 14–18 years
Kumra et al. 2008 [28] Schizophrenia, schizoaffective disorder (K-SADS-PL) Clozapine 25–900 mg/day
Olanzapine 30 mg/day
12 Aged 10–18 years
Pandina et al. 2012 [29] Schizophrenia
(DSM-IV + K-SADS-PL)
Risperidone 2–6 mg/daya 24 or 48a Aged 13–17 years; PANSS 40–120
Ruan et al. 2010 [30] Schizophrenia
(DSM-IV-TR)
Risperidone 25–50 mg biweekly 24 Aged 13–18 years; PANSS ≤ 80
Schimmelmann et al. 2007 [31] Schizophrenia, schizoaffective and schizophreniform disorder
(DSM-IV)
Quetiapine 200–800 mg/day 12 Aged 12–17 years; PANSS ≥ 60
  1. BPRS Brief psychiatric rating scale, DSM Diagnostic and Statistical Manual of Mental Disorders, K-SADS-PL Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children – Present and Lifetime Version, PANSS Positive and negative syndrome scale, TR text revision
  2. aPatients were allocated to three treatment arms as treatment-naïve, treatment-experienced, and open-label treatment. Patients in the treatment-naïve and treatment-experienced arms were evaluated at 24 weeks and patients in the open-label arm were evaluated at 48 weeks
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