A clinical guidance tool to improve the care of children hospitalized with severe pneumonia in Lusaka, Zambia

BMC Pediatrics

Table 4 Differences in the effect of the intervention on mortality by age and HIV infection status

	N pre/post intervention period	In hospital mortality in the pre/post intervention period (%)	Adjusted relative risk (95 % CI)	p-value for interaction
Age^a
< 6 months	240/124	20.8/14.5	0.64 (0.40, 1.02)	0.05
≥ 6 months	203/126	14.8/22.2	1.23 (0.79, 1.92)	ref
HIV infection status^b
Unexposed/uninfected	273/162	11.4/13.6	1.20 (0.73, 1.99)	ref
Exposed/uninfected	107/40	24.3/12.5	0.48 (0.22, 1.04)	0.05
Infected	63/48	36.5/39.6	0.82 (0.51, 1.33)	0.28
Pneumonia severity^c
Severe	316/154	11.7/11.0	0.97 (0.57, 1.64)	ref
Very severe	127/96	33.9/30.2	0.85 (0.58, 1.24)	0.68
Pneumonia season^d
Low	251/154	21.9/21.4	0.83 (0.57, 1.20)	ref
High	192/96	13.0/13.5	1.08 (0.60, 1.93)	0.45
Weight-for-age z-score^e
< −2	97/36	28.9/27.8	0.58 (0.31, 1.10)	0.21
≥ −2	321/204	14.3/14.2	0.93 (0.63, 1.37)	ref

^amodel was adjusted for weight-for-age z-score, severity of pneumonia, HIV status, and pneumonia season
^bmodel was adjusted for age, weight-for-age z-score, severity of pneumonia, and pneumonia season
^cmodel was adjusted for weight-for-age z-score, HIV status, and pneumonia season
^dmodel was adjusted for weight-for-age z-score, HIV status, and severity of pneumonia
^emodel was adjusted for age, HIV status, severity of pneumonia, and pneumonia season

ISSN: 1471-2431