Fig. 1
From: A Suspicion Index to aid screening of early-onset Niemann-Pick disease Type C (NP-C)
The early-onset NP-C SI. Symptoms were scored based on the strength of association with a diagnosis of NP-C in the present cohort. The CNS signs ataxia and mental regression only contribute additional RPS points in the presence of other CNS signs (gelastic cataplexy, VSGP) or splenomegaly. CNS, central nervous system; RPS, risk prediction score; SI, Suspicion Index; VSGP, vertical supranuclear gaze palsy