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Table 3 Risk factors for child mortality

From: HIV-exposed children account for more than half of 24-month mortality in Botswana

 

All children (N = 3033)

HIV-exposed uninfected children (N = 1483)

Selected risk factors for mortality

Univariate HR

(95 % CI)

Adjusted HR

(95 % CI)

Univariate HR

(95 % CI)

Adjusted HR

(95 % CI)

Non-tertiary delivery site

1.1 (0.7,1.5)

1.2 (0.7, 1.9)

Infant congenital abnormalities

2.5 (0.9,6.8)

1.9 (0.7, 5.4)

4.6 (1.7, 12.5)

5.5 (1.3, 23.8)

Infant birth injuries

1.3 (0.6,2.7)

1.8 (0.7, 4.5)

2.7 (0.8, 9.0)

Infant preterm (<37 weeks)

1.4 (0.9,2.3)

1.1 (0.7, 1.8)

1.4 (0.8, 2.4)

1.4 (0.7, 2.9)

Never Breastfed

2.5 (1.7,3.8)

a

1.0 (0.5,1.9)

1.4 (0.5, 3.7)

Introduction of solid food < 6 months

0.7 (0.3,1.4)

0.9 (0.3,2.4)

Season of birth: Jan–Mar

1.9 (1.3,2.7)

1.8 (1.2, 2.6)

1.6 (1.0,2.5)

1.4 (0.8, 2.8)

Infant HIV-infectedb

30.0 (15.0,60.0)

21.7 (10.3, 46)

Infant HIV-exposedb

3.5 (2.2,5.5)

2.7 (1.6, 4.5)

Water not piped directly into home

2.4 (1.2,4.7)

1.8 (0.8, 2.6)

2.1 (0.9. 5.1)

1.6 (0.5, 5.5)

No refrigerator in the home

1.2 (0.8,1.7)

1.0 (0.6, 1.6)

No/primary maternal education

2.1 (1.1,4.4)

1.5 (0.8, 2.6)

1.8 (1.0, 3.2)

2.7 (1.2, 6.3)

No indoor toilet

1.9 (1.1, 3.2)

1.0 (0.5, 2.0)

1.6 (0.8, 3.3)

0.7 (0.3, 1.9)

Cooking method: Paraffin or woodburning stove

1.4 (1.0,2.1)

1.0 (0.9, 1.6)

1.0 (0.6, 1.6)

Maternal Death

9.0 (2.2,36.7)

8.9 (2.1,37.1)

c

c

Maternal Age

1.0 (1.0,1.0)

1.0 (0.9,1..0)

1.0 (1.1)

1.0 (0.9,1.0)

Mother Primiparous

0.6 (0.1,1.0)

0.9 (0.5,1.5)

1.2 (1.7,2.2)

0.8 (0.3,2.1)

Mother Married

0.6 (0.3,1.4)

0.5 (0.2,1.6)

0.6 (0.1, 2.5)

Maternal ZDV monotherapy in pregnancy (reference 3-drug ART)

1.3 (0.8,2.1)

1.1 (0.6, 2.1)

Maternal CD4 < 250 cells/mL

0.9 (0.4,2.1)

  1. aDue to collinearity between HIV-exposure status and feeding choice (breast vs. formula feeding), feeding was unable to be added to the multivariate model. When modeled separately, without HIV-exposusre status, the aHR of never breastfeeding was 2.3 (95 % CI 1.5,3.5)
  2. bReference group is HIV-unexposed infants (HU)
  3. cAmong all HEU infants who died, there were no maternal deaths. Therefore, maternal deaths could not be included as a covariate in the HEU model