From: HIV-exposed children account for more than half of 24-month mortality in Botswana
All children (N = 3033) | HIV-exposed uninfected children (N = 1483) | |||
---|---|---|---|---|
Selected risk factors for mortality | Univariate HR (95 % CI) | Adjusted HR (95 % CI) | Univariate HR (95 % CI) | Adjusted HR (95 % CI) |
Non-tertiary delivery site | 1.1 (0.7,1.5) | – | 1.2 (0.7, 1.9) | – |
Infant congenital abnormalities | 2.5 (0.9,6.8) | 1.9 (0.7, 5.4) | 4.6 (1.7, 12.5) | 5.5 (1.3, 23.8) |
Infant birth injuries | 1.3 (0.6,2.7) | – | 1.8 (0.7, 4.5) | 2.7 (0.8, 9.0) |
Infant preterm (<37 weeks) | 1.4 (0.9,2.3) | 1.1 (0.7, 1.8) | 1.4 (0.8, 2.4) | 1.4 (0.7, 2.9) |
Never Breastfed | 2.5 (1.7,3.8) | –a | 1.0 (0.5,1.9) | 1.4 (0.5, 3.7) |
Introduction of solid food < 6 months | 0.7 (0.3,1.4) | – | 0.9 (0.3,2.4) | – |
Season of birth: Jan–Mar | 1.9 (1.3,2.7) | 1.8 (1.2, 2.6) | 1.6 (1.0,2.5) | 1.4 (0.8, 2.8) |
Infant HIV-infectedb | 30.0 (15.0,60.0) | 21.7 (10.3, 46) | – | – |
Infant HIV-exposedb | 3.5 (2.2,5.5) | 2.7 (1.6, 4.5) | – | – |
Water not piped directly into home | 2.4 (1.2,4.7) | 1.8 (0.8, 2.6) | 2.1 (0.9. 5.1) | 1.6 (0.5, 5.5) |
No refrigerator in the home | 1.2 (0.8,1.7) | – | 1.0 (0.6, 1.6) | – |
No/primary maternal education | 2.1 (1.1,4.4) | 1.5 (0.8, 2.6) | 1.8 (1.0, 3.2) | 2.7 (1.2, 6.3) |
No indoor toilet | 1.9 (1.1, 3.2) | 1.0 (0.5, 2.0) | 1.6 (0.8, 3.3) | 0.7 (0.3, 1.9) |
Cooking method: Paraffin or woodburning stove | 1.4 (1.0,2.1) | 1.0 (0.9, 1.6) | 1.0 (0.6, 1.6) | – |
Maternal Death | 9.0 (2.2,36.7) | 8.9 (2.1,37.1) | –c | –c |
Maternal Age | 1.0 (1.0,1.0) | 1.0 (0.9,1..0) | 1.0 (1.1) | 1.0 (0.9,1.0) |
Mother Primiparous | 0.6 (0.1,1.0) | 0.9 (0.5,1.5) | 1.2 (1.7,2.2) | 0.8 (0.3,2.1) |
Mother Married | 0.6 (0.3,1.4) | – | 0.5 (0.2,1.6) | 0.6 (0.1, 2.5) |
Maternal ZDV monotherapy in pregnancy (reference 3-drug ART) | – | – | 1.3 (0.8,2.1) | 1.1 (0.6, 2.1) |
Maternal CD4 < 250 cells/mL | – | – | 0.9 (0.4,2.1) | – |