Table 3 Efficacy outcomes of fluconazole prophylaxis
| Â | Pre-prophylaxis | Fluconazole prophylaxis | P value |
|---|---|---|---|
Primary outcomes | |||
 Invasive fungal infection | 7/159 (4.4) | 12/242 (5.0) | 0.80 |
 Invasive fungal infection in birth weight <750 g | 6/68 (8.8) | 9/99 (9.1) | 0.95 |
 Invasive fungal infection, event per 1,000 patient days | 0.56 | 0.56 | 0.99 |
Secondary outcomes | |||
 Death | 26/159 (16.4) | 31/264 (11.7) | 0.18 |
 Death from invasive fungal infection | 3/26 (11.5) | 1/31 (3.2) | 0.32 |
 Invasive fungal infection related death | 2/7 (28.6) | 1/12 (8.3) | 0.52 |
 Baseline fungal colonization | 4/149 (2.7) | 3/224 (1.3) | 0.71 |
 Fungal colonization | 88/149 (59.1) | 76/224 (33.9) | <0.001 |
 Single:Multiple(≥2 sites) | 21:67 | 17:59 | 0.44 |
 Axilla:Ear:Nasopharynx:Throat/trachea:Anus:Urine | 46:25:2:8:29:14 | 33:19:4:10:19:15 | - |
 Fungal colonization to invasive infection | 4/88 (4.6) | 6/76 (7.9) | 0.52 |
 Length of hospitalization, mean ± SD, day | 90 ± 51 | 88 ± 52 | 0.74 |