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Table 2 Summary of all other pediatric cases of RDD described between 2004 and 2014 (our case and cases in which only surgery was used were not included; i.e. 33 cases)

From: Unusual presentation of Rosai-Dorfman disease in a 14-month-old Italian child: a case report and review of the literature

Systemic symptoms

Fever

Anemia

Fatigue

None

Not mentioned

# of cases

3

5

1

10

9

Ref.

[25, 29, 30]

[3, 24, 27, 29, 31]

[32]

[17, 20, 24, 28, 30, 3235]

[6, 17, 23, 24, 26, 3638]

Lesion location

Lymph nodes

Bone

Brain

Other

 

# of cases

18

8

5

6

 

Ref.

[17, 22, 25, 2736, 39, 40]

[6, 22, 24, 34, 37, 40]

[20, 24, 26, 38, 39]

[3, 17, 23, 30, 32, 41]

 

Successful of main treatment

Corticosteroids

Chemotherapy

Corticosteroids + chemotherapy

Others

None

# of cases

6

7

5

5

10

Ref.

[3, 23, 30, 33, 36]

[6, 2224, 32, 37, 40]

[17, 24, 34, 39]

[20, 2527, 38]

[17, 24, 29, 31, 28, 35, 41]

Outcome

Complete regression

Partial regression

Clinical stability

Symptoms free (no precise information on disease outcome)

Death

# of cases

11

12

6

3

1

Ref.

[6, 22, 2527, 28, 33, 35, 36, 38, 39]

[3, 23, 24, 2932, 34, 39, 40]

[17, 24, 37]

[17, 29, 41]

[20]