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Table 5 Multivariate analysis for desaturation, severe desaturation, any TIAEs and severe TIAEs

From: The number of tracheal intubation attempts matters! A prospective multi-institutional pediatric observational study

  1 attempt (n = 1256) 2 attempts (n = 503) ≥ 3 attempts (n = 321)
Desaturation (SpO2 < 80 %) 1.0 (baseline) 2.9 6.5
(OR, 95 % CI, p-value) [2.3–3.7, <0.001] [5.0–8.5, <0.001]
Severe desaturation (SpO2 < 70 %) 1.0 (baseline) 3.1 5.7
(OR, 95 % CI, p-value) [2.4–4.0, <0.001] [4.3–7.5, <0.001]
Any TIAEsa 1.0 (baseline) 3.7 5.5
(OR, 95 % CI, p-value) [2.9–4.9, <0.001] [4.1–7.4, <0.001]
Severe TIAEs 1.0 (baseline) 1.6 1.8
(OR, 95 % CI, p-value) [1.1–2.4, 0.02] [1.1–2.8, 0.01]
  1. Odds ratio, 95 % Confidence interval and p-value were calculated by multivariate logistic regression
  2. Analysis adjusted for history of difficult airway, upper airway obstruction, age as a categorical variable (infant, 1–7 year, 8 or older). Note that history of difficult airway and signs of upper airway obstruction were identified as risk for multiple attempts [23]
  3. Hosmer-Lemeshow goodness of fit test for each model: desaturation (SpO2 < 80 %): Chi2 (29) = 19.90, p = 0.90; severe desaturation (SpO2 < 70 %): Chi2 (29) = 20.69, p = 0.87; Any TIAEs: Chi2 (29) = 24.92, p = 0.68; Severe TIAEs: Chi2 (29) = 20.68, p = 0.87
  4. For outcomes with any TIAEs, we ran a separate multiple logistic regression model without including esophageal intubation with immediate recognition as a part of TIAE definition. The result is shown in Additional file 2: Table S1
  5. OR denotes odds ratio, CI denotes confidence interval
  6. aTIAE denotes adverse Tracheal Intubation Associated Events