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Table 2 Top-ranked variables distinguishing ASD from Control subjects and their correlations with neurodevelopmental measures

From: Salivary miRNA profiles identify children with autism spectrum disorder, correlate with adaptive behavior, and implicate ASD candidate genes involved in neurodevelopment

Group Mean/Median comparisons

Logistic regression classifications

Neurodevelopmental correlations

 

miRNA

M-W -val

FDR

Z diff

Cohen’s d

Wald

p-Val

AUC

Accuracy

age(Yrs)

ADOS comm

ADOS social

ADOS C+S

VABS comm

VABS ADL

VABS social

VABS comp

Sequence

miRBase ID

miR-628-5p

0.0001

0.027

1.13

0.83

11.21

0.001

0.90

0.73

−0.260

−0.037

−0.286

−0.210

−0.346

−0.354

−0.381

−0.399

AUGCUGACAUAUUUACUAGAGG

MIMAT0004809

miR-127-3p

0.003

0.040

0.62

0.96

2.55

0.110

0.86

0.64

−0.347

−0.249

−0.189

−0.149

−0.363

−0.414

−0.463

−0.453

UCGGAUCCGUCUGAGCUUGGCU

MIMAT0000446

miR-27a-3p

0.0013

0.110

−0.089

0.90

7.00

0.008

0.78

0.71

0.141

−0.036

−0.028

−0.035

0.353

0.357

0.414

0.418

UUCACAGUGGCUAAGUUCCGC

MIMAT0000084

miR-335-3p

0.0014

0.089

0.95

0.89

7.40

0.007

0.92

0.73

−0.199

0.247

−0.075

0.019

−0.462

−0.512

−0.492

−0.505

UUUUUCAUUAUUGCUCCUGACC

MIMAT0004703

miR-2467-5p-

0.0015

0.074

0.87

0.91

7.11

0.008

0.82

0.73

−0.020

−0.138

0.003

−0.003

−0.381

−0.365

−0.368

−0.399

UGAGGCUCUGUUAGCCUUGGCUC

MIMAT0019952

miR-30e-5p

0.0017

0.069

−0.90

0.90

7.52

0.006

0.77

0.76

0.191

0.076

−0.278

−0.260

0.368

0.496

0.499

0.496

UGUAAACAUCCUUGACUGGAAG

MIMAT0000692

miR-28-5p

0.0021

0.072

0.90

0.90

8.25

0.004

0.81

0.69

0.190

0.054

0.379

0.332

−0.405

−0.422

−0.420

−0.431

AAGGAGCUCACAGUCUAUUGAG

MIMAT0000085

miR-191-5p

0.0029

0.089

0.94

0.89

7.97

0.005

0.76

0.69

−0.171

0.336

0.221

0.337

−0.267

−0.206

−0.291

−0.299

CAACGGAAUCCCAAAAGCAGCUG

MIMAT0000440

miR-23-3p

0.0031

0.085

−0.90

0.90

7.63

0.006

0.76

0.69

0.151

−0.115

−0.268

−0.223

0.421

0.489

0.460

0.487

AUCACAUUGCCAGGAUUUCC

MIMAT0000078

miR-3529-5p

0.0033

0.082

0.80

0.93

6.80

0.009

0.76

0.64

−0.091

0.325

0.230

0.290

−0.458

−0.353

−0.466

−0.462

AACAACAAAAUCACUAGUCUUCCA

MIMAT0022741

miR-218-5p

0.0035

0.077

0.59

0.96

3.43

0.064

0.79

0.73

0.045

−0.059

0.061

0.058

−0.246

−0.261

−0.314

−0.296

UUGUGCUUGAUCUAACCAUGU

MIMAT0000275

miR-7-5p

0.0045

0.091

0.59

0.97

3.19

0.074

0.86

0.73

0.007

−0.095

0.143

0.090

−0.405

−0.389

−0.414

−0.447

UGGAAGACUAGUGAUUUUGUUGU

MIMAT0000252

miR-32-5p

0.0051

0.097

−0.86

0.91

7.07

0.008

0.75

0.73

0.238

0.269

0.146

0.139

0.297

0.358

0.386

0.361

UAUUGCACAUUUACUAAGUUGCA

MIMAT0000090

miR-140-3p

0.0078

0.137

0.64

0.96

4.25

0.039

0.84

0.73

−0.046

−0.200

−0.163

−0.241

−0.152

−0.243

−0.217

−0.233

UACCACAGGGUAGAACCACGG

MIMAT0004597

  1. Abbreviation: AUC area under the curve, FDR false discovery rate, C+S Communication + Socialization, M-W p-val Mann-Whitney p-value, VABS Vineland Adaptive Behavior Scales, Wald Wald statistic
  2. Note that overall, the 14 miRNAs listed were 91% accurate, although accuracy for individual miRNAs did not exceed 0.76. Correlations shown in bold were significant (p <0.05). Also note that several in RNAs showed robust correlations with Vineland scores