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Table 1 Characteristics at presentation of 48 probands with familial constitutional delay of puberty

From: Constitutional delay of puberty: presentation and inheritance pattern in 48 familial cases

 

GIRLS (n = 14)

BOYS (n = 34)

p

 

n

m ± SD

n

m ± SD

 

Age at onset, years

14

13.65 ± 0.77

29

15.65 ± 1.9

< 0.01

Age at evaluation, years

14

14.05 ± 0.35

34

15.1 ± 0.42

< 0.01

BMI, SDS

14

−1.5 ± 0.7

34

−2 ± 1.41

NS

BA delay, years

12

2 ± 1.13

27

3.05 ± 2.4

NS

Tanner pubic hair

13

3 ± 0

33

2.5 ± 0.7

NS

Age at menarche in mothers, years

13

15.75 ± 0.35

30

14.25 ± 1.8

0.01

IGF 1, ng/mL

12

190.5 ± 77

28

233 ± 83

NS

LH peak, IU/L

4

5.25 ± 0.63

11

5.9 ± 1.8

NS

FSH peak, IU/L

4

11.6 ± 6.6

11

1.85 ± 0.07

NS

LH/FSH peak ratio

4

0.55 ± 0.35

11

3.2 ± 1.13

NS

Estradiol, pg/mL

9

2.5 ± 0.7

NA

NA

NA

Testicular volume index, cm2

NA

NA

33

7 ± 4.2

NA

Testosterone, ng/mL

NA

NA

28

0.46 ± 0.21

NA

  1. NA not applicable, NS not significant