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Table 7 Follow-up characteristics of patients with Rb according to subgroups

From: Retinoblastoma in a pediatric oncology reference center in Southern Brazil

Systemic dissemination (n= 140 patients)
  Metastatic (n = 15) Age; Age dx (min-max) (months) Non-metastatic (n = 125) Age; Age dx (min-max) (months) P
Age at first signs and symptoms 32.1; 24.0 (1.0-129.0) 16.4; 11.0 (0-84.0) 0.107
Age at diagnosis 46.5; 26.0 (2.0-206.0) 20.8; 16.0 (1.0-84.0) 0.024
Time to diagnosis 14.3; 4.0 (1.0-77.0) 4.4; 3.0 (0-26.0) 0.123
Duration of follow-up (months) 77.7 (20.6-134.7) 345.2 (325.6-364.7) <0.001
Hereditary criteria (n= 140 patients)
  Hereditary (n = 52) Age; Age dx (min-max) (months) Non-hereditary (n = 88) Age; Age dx (min-max) (months) P
Age at first signs and symptoms 12.3; 6.5 (0-84.0) 21.6; 14.0 (0-129.0) 0.001
Age at diagnosis 15.9; 10.5 (1.0-84.0) 28.0; 21.5 (1.0-206.0) <0.001
Time to diagnosis 3.7; 2.0 (0-20.0) 6.5; 3.0 (0-77.0) 0.074
Duration of follow-up (months) 318.2 (280.2-356.2) 274.0 (250.8-297.2) 0.844
Disease extension for each eye (n= 187 eyes involved)
  Intraocular (n = 133) Age; Age dx (min-max) (months) Extraocular (n = 54) Age; Age dx (min-max) (months) P
Age at first signs and symptoms 13.6; 8.0 (0-84.0) 22.7; 12.0 (0-129.0) 0.001
Age at diagnosis 16.9; 13.0 (1.0-84.0) 31.3; 24.0 (1.0-206.0) <0.001
Time to diagnosis 3.4; 2.0 (0-20.0) 8.5; 4.0 (0-77.0) <0.001
Duration of follow-up 352.9 (336.0-369.8) 252.7 (204.7-301.3) <0.001