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Table 6 Follow-up characteristics of patients with Rb according to subgroups

From: Retinoblastoma in a pediatric oncology reference center in Southern Brazil

Laterality (n = 140 patients)
  Unilateral (n = 91) Age; Age dx (min-max) (months) Bilateral (n = 46) Age; Age dx (min-max) (months) Trilateral (n = 3)
Age; Age dx (min-max) (months)
P
Age at first signs and symptoms 21.7; 15.0 (0-129.0) 10.3; 6.0 (0-84.0) 29.0; 24.0 (3.0-60.0) [24.0] <0.001
Age at diagnosis   13.4; 8.0 (1.0-84.0) 40.3; 26.0 (15.0-80.0) <0.001
Time to diagnosis 28.1; 22.0 (1.0-206.0) 3.1; 2.0 (0-14.0) 11.3; 12.0 (2.0-20.0) 0.029
Duration of follow-up (months) 6.4; 3.0 (0-77.0)    
275.6 (253.2-297.9) 334.9 (299.3-370.5) 22.3 (2.9-42.7) <0.001
Laterality for each eye (n = 187 eyes involved)
  Unilateral (n = 91) Age; Age dx (min-max) (months) Bilateral (n = 92) Age; Age dx (min-max) (months) Trilateral (n = 4) Age; Age dx (min-max) (months)  
Time to diagnosis between IO and EO in each subgroup IO: 4.0; 2.0 (0-20.0) IO: 2.9; 2.0 (0-14.0) IO: 2.0; 2.0 (2.0-2.0)  
EO: 10.8; 4.5 (1.0-77.0) EO: 4.2; 4.0 (0-12.0) EO: 11.3; 12.0 (2.0-20.0)  
P= 0.003 P = 0.147 P = 0.346  
Duration of follow-up between IO and EO in each subgroup (months) IO: 293.0 (273.3-312.8) IO: 355.7 (334.6-376.9) IO: 4.0 (4.0-4.0)  
EO: 230.9 (180.4-281.4) EO: 255.5 (174.8-336.3) EO: 22.3 (2.9-41.7)  
P= 0.002 P = 0.001 P = 0.317  
  1. dx diagnosis, CI confidence interval; age, time to diagnosis and duration of follow-up are expressed in months. Kruskal-Wallis test was used for analysis of ages and time to diagnosis; Log-rank test was used to estimate duration of follow-up. Disease extension, IO intraocular, EO extraocular. Time to diagnosis: time between onset of the first sign or symptom and diagnosis (months); duration of follow-up: difference between the patient’s age at diagnosis and their age at the time of the last consultation (if alive) or date of death (months)