Table 2 Vitamins and metabolites in infants aged 6 weeks, 4 months and 6 months according to nutrition^a

Number

At 6 weeks

32

48

At 4 months^c

27

40

At 6 months^d

26

40

Serum cobalamin, pmol/L

At 6 weeks

372 (294, 444)

234 (158, 321)

<0.001

At 4 months

476 (404, 573)

281 (224, 423)

<0.001

At 6 months

497 (387, 622)

321 (198, 451)

<0.001

P ^e

<0.001

<0.001

Serum folate, nmol/L

At 6 weeks

56.4 (30.6, 118,4)

27.2 (21.1, 119.9)

0.09

At 4 months

61.4 (44.0, 84.5)

64.4 (41.8, 85.6)

0.96

At 6 months

53.9 (34.2, 67.0)

50.5 (39.9, 62.5)

0.69

P ^e

0.48

0.02

Plasma PLP, nmol/L

At 6 weeks

274 (201, 337)

79 (42, 132)

<0.001

At 4 months

230 (155, 281)

135 (88, 161)

<0.001

At 6 months

184 (123, 278)

122 (93, 162)

<0.001

P ^e

0.006

0.007

Plasma riboflavin, nmol/L

At 6 weeks

62.2 (43.1, 84.1)

16.3 (13.8, 22.6)

<0.001

At 4 months

36.3 (21.0, 47.2)

12.5 (9.8, 17.1)

<0.001

At 6 months

33.5 (22.7, 49.5)

14.8 (10.6, 18.5)

<0.001

P ^e

0.001

0.02

Plasma tHcy, μmol/L

At 6 weeks

7.24 (5.91, 8.42)

7.44 (6.31, 9.07)

0.36

At 4 months

5.90 (5.14, 7.26)

8.11 (6.40, 10.32)

<0.001

At 6 months

5.38 (4.38, 6.96)

7.35 (5.78, 9.02)

0.001

P ^e

<0.001

0.50

Plasma MMA,

μmol/L

At 6 weeks

0.61 (0.38, 1.14)

0.54 (0.28, 1.87)

0.59

At 4 months

0.22 (0.20, 0.39)

0.50 (0.21, 1.32)

0.01

At 6 months

0.19 (0.16, 0.36)

0.59 (0.33, 1.20)

<0.001

P ^e

<0.001

0.29