| |
Baseline
|
Follow-up
|
p
|
|---|
|
Age, years
|
13.7 (10.0–16.8)
|
14.6 (10.9–17.8)
|
<0.0001***
|
|
BMI SDS
|
2.80 (1.49–3.85)
|
2.56 (0.18–4.68)
|
0.001**
|
|
VAT, cm3
|
83 (21–361)
|
73 (15–396)
|
0.01*
|
|
SAT, cm3
|
282 (97–518)
|
262 (74–527)
|
0.14
|
|
LFC, %
|
3.0 (0.5–67.0)
|
3.0 (0.5–32.0)
|
0.01*
|
|
Hepatic steatosis, fraction
|
28 % (11/40)
|
20 % (8/40)
|
0.26
|
|
MFC, %
|
7.4 (1.2–26.3)
|
4.8 (0.5–39.6)
|
0.01*
|
|
Muscle steatosis, fraction
|
75 % (30/40)
|
45 % (18/40)
|
0.007**
|
|
Triglyceride, mmol/l
|
0.9 (0.2–2.3)
|
1.0 (0.3–2.0)
|
0.78
|
|
HDL cholesterol, mmol/l
|
1.2 (0.7–1.7)
|
1.2 (0.8–2.1)
|
0.03*
|
|
LDL cholesterol, mmol/l
|
2.3 (1.1–4.2)
|
2.4 (1.0–3.8)
|
0.02*
|
|
Non-HDL cholesterol, mmol/l
|
2.8 (1.2–4.7)
|
2.8 (1.2–4.4)
|
0.02*
|
|
Plasma glucose, mmol/l
|
5.1 (4.2–6.2)
|
5.1 (4.4–5.9)
|
0.42
|
|
Serum insulin, pmol/l
|
83 (11–271)
|
87 (14–226)
|
0.99
|
|
HbA1c, mmol/l
|
35 (28–42)
|
34 (26–40)
|
0.04*
|
|
ALT, U/l
|
22 (11–126)
|
22 (10–69)
|
0.67
|
|
GGT, U/l
|
18 (5–134)
|
16 (9–33)
|
0.72
|
- Data are medians (range) due to a non-normal distribution
- ALT alanine transaminase; BMI body mass index; GGT gamma-glutamyl transferase; HDL high density lipoprotein; HbA1c glycosylated hemoglobin; IMCL intramyocellular lipid content; LDL low density lipoprotein; LFC liver fat content; MFC muscle fat content; SAT subcutaneous adipose tissue volume; SDS standard deviation score; VAT visceral adipose tissue volume
- P value for group differences: *** p <0.001; ** p <0.01; * p <0.05
