Table 4 Cox Regression Analysis for Treatment Failure Using the Per Protocol and Intention to Treat Analysis up to 14 days
Characteristic | Per-protocol analysis | Intention to treat analysis | ||||||
|---|---|---|---|---|---|---|---|---|
Hazard ratio | 95 % CI | p-value | Hazard ratio | 95 % CI | p-value | |||
Treatment group | ||||||||
Home | 1.00 | 1.00 | ||||||
Hospital | 1.32 | 0.93 | 1.88 | 0.12 | 1.61 | 1.16 | 2.24 | 0.00 |
Age group | ||||||||
Infants (3–11 months old) | 1.00 | 1.00 | ||||||
Children (12–59 months old) | 0.65 | 0.45 | 0.93 | 0.02 | 0.69 | 0.49 | 0.96 | 0.03 |
Exclusive breast feeding | ||||||||
No | 1.00 | 1.00 | ||||||
Yes | 1.52 | 0.98 | 2.36 | 0.06 | 1.46 | 0.99 | 2.16 | 0.06 |
Antibiotics prior to enrollment | ||||||||
No | 1.00 | 1.00 | ||||||
Yes | 1.79 | 1.06 | 3.02 | 0.03 | 1.72 | 1.07 | 2.76 | 0.02 |
Fuel used for cooking | ||||||||
Low polluting fuel | 1.00 | 1.00 | ||||||
High polluting fuel | 1.43 | 0.98 | 2.10 | 0.06 | 1.51 | 1.06 | 2.15 | 0.02 |
Study Site | ||||||||
Chandigarh | 1.00 | 1.00 | ||||||
Chennai | 0.18 | 0.09 | 0.33 | 0.00 | 0.41 | 0.26 | 0.64 | 0.00 |
Nagpur | 0.58 | 0.38 | 0.91 | 0.02 | 0.63 | 0.42 | 0.96 | 0.03 |
Pune | 2.33 | 0.84 | 6.48 | 0.11 | 2.78 | 1.11 | 6.97 | 0.03 |