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Table 3 Summary of etiologies of conjugated hyperbilirubinemia in infancy by disease category

From: Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects

  Total number % of total
Idiopathic Neonatal Hepatitis (INH) 440 26.00 %
Extrahepatic Biliary Atresia (EHBA) 438 25.89 %
Infection 194 11.47 %
TPN associated cholestasis 109 6.44 %
Metabolic disease 74 4.37 %
Alpha-1 Antitrypsin deficiency 70 4.14 %
Perinatal hypoxia/ischemia 62 3.66 %
Interlobular bile duct paucity 42 2.48 %
Choledochal cyst 36 2.13 %
Hypopituitarism/hypothyroidism 33 1.95 %
Hemolysis 24 1.42 %
Inspissated bile syndrome 23 1.36 %
Progressive Familial Intrahepatic Cholestasis (PFIC) 17 1.00 %
Alagille syndrome 16 0.95 %
Cystic Fibrosis 15 0.89 %
Other a 99 5.85 %
Total 1692 100.00 %
  1. a See text for complete list and count of “other” diagnoses