Skip to main content

Table 5 Prevalence of OM pathogens in 144 ear discharge (ED) swabs from 107 children with AOMwiP or CSOM, by vaccination groups

From: Reduced middle ear infection with non-typeable Haemophilus influenzae, but not Streptococcus pneumoniae, after transition to 10-valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine

 

PCV7

PHiD-CV10

Absolute Risk Difference [95 % CI]

P value

 

N, Mean (SD)

%

N, Mean (SD)

%

  

ED swabs

85

 

59

   

Children with ED

60a

 

47

   

Mean age (mo)

20 (7.6)

 

18 (6.9)

   

Bilateral ED swabs

19

 

13

   

 CSOM

11

 

8

   

 AOMwiP

6

 

3

   

 AOMwiP and CSOM

2

 

2

   

All ED swabs

85

 

59

   

  > =3-dose schedule

77/85

91 %

53/59

90 %

  

 One dose PCV13

0

 

9/59

15 %

  

 NTHi

39/73m-

53 %

19/55

35 %

−19 %

0.03

[−36 to −2]

 Spn

20/83

24 %

8/56

14 %

−10 %

0.16

[−23 to 3]

 NTHi and Spn

12/69

17 %

5/55

9 %

−8 %

0.18

[−20 to 3]

 Mcat

1/61

2 %

4/55

7 %

6 %

0.14

[−2 to 13]

 Sa

44/82

54 %

24/56

43 %

−11 %

0.21

[−28 to 6]

 Spn serotypesb

10A(n = 4) 7Fc(n = 2) 11Cd(n = 2) 10F 12F 16Fd 17Fc 19Ad 19Fd 23Fc 6A 6C

11Ad(n = 2) 15Ac 16Fd 19Fd 21 22A 35F

  

Children with ED (Bilateral data combined)

60

 

47

   

  > =3 dose schedule

54/60

90 %

42/47

89 %

  

 One dose PCV13

0

 

9/47

19 %

  

 NTHi

33/54m-

61 %

15/44

34 %

−27 %

0.008

[−46 to −8]

 Spn

15/60

25 %

8/45

18 %

−7 %

0.38

[−23 to 8]

 NTHi and Spn

11/60

18 %

5/45

11 %

−7 %

0.31

[−21 to 6]

 Mcat

1/46

2 %

3/44

7 %

5 %

0.27

[−4 to 13]

 Sa

35/59

59 %

22/45

49 %

−10 %

0.29

[−30 to 9]

  1. a 53 children in the PCV7 group had also received PPV23
  2. b Strains within this serotype are:
  3. c Azithromycin non-susceptible (MIC > 0.5 mg/L)
  4. d Penicillin non-susceptible (MIC > 0.06 mg/L)
  5. e Non-susceptible to both
  6. f- ED culture not affected by masking