Incidence and serotype distribution of invasive group B streptococcal disease in young infants: a multi-country observational study

Table 3 Incidence rate of invasive group B streptococcal disease and case fatality ratio in the study population***

GBS incidence rate
	Panama			Dominican Republic*						Hong Kong
	Panama			Site 1			Site 2			Hong Kong
	EOD	LOD	Total	EOD			LOD			EOD	LOD	Total
Observed GBS cases	12	9	21	42			12**			10	5	15
Live births	15 500	15 500	15 500	17 867			70 297			13 244	13 244	13 244
Incidence rate per 1 000 live births	0•77 (0•44–1•35)	0•58 (0•31–1.10)	1•35 (0•89–2•07)	2•35 (1•74–3•18)			0•17 (0•10–0•30)			0•76 (0•41–1•39	0•38 (0•16–0•88)	1•13 (0•69–1•87)
Number of days hospitalized
Mean (SD)	11 (5)			9 (6)			6 (5)			16 (4)
Median (Range)	11 (0–16)			10 (0–39)			6 (0–13)			15 (8–24)
Case Fatality Ratio
	EOD	LOD	Total	EOD	LOD	Total	EOD	LOD	Total	EOD	LOD	Total
Deaths	2	1	3	9	-	9	1	5	6	1	0	1
Number of cases	12	9	21	42	-	42	3	12	15	10	5	15
Case fatality ratio	16•7 % (4•7–44•8)	11•1 % (2•0–43•5)	14•3 % (5•0–34•6)	21•4 % (11•7–35•9)	-	21•4 % (11•7–35•9)	33•3 % (6•1–79•2)	41•7 % (19•3–68•0)	40•0 % (19•8–64•3)	10•0 % (1•8–40•4)	0 % (0–43•4)	6•7 % (1•2–29•8)

*An overall early and late onset disease (EOD and LOD) incidence rate for Dominican Republic was not calculated because Site 1 (maternity) used a hospital-based denominator and Site 2 (pediatric) used a community-based denominator. **The three EOD cases recorded at Site 2 (pediatric) were not included in incidence calculations as cases were from different hospital birth cohorts without a clear denominator. *** Incidence for Bangladesh is not represented as no cases were identified among 4227 births. However the 95 % confidence interval around the incidence estimate is 0–0.9 per 1000 LB

ISSN: 1471-2431