Table 3 Performance of reported adherence for detecting virological failure in HIV-infected infants treated early by cART for at least 3 months (ANRS-PEDIACAM Study, 2008–2013, Cameroon)
3a - All children | AUC | Sensitivity | Specificity | PPV | NPV | LR+ | LR− | ||||||||
N | % | n | % | p | % | (n/N) | % | (n/N) | % | (n/N) | % | (n/N) | |||
At M3 | 146 | ||||||||||||||
VL ≥ 1000 cp /mL | 41.8 | (61) | |||||||||||||
≥ 1 current missed (A) | 27. 4 | (40) | 49.4 | 0.870 | 26.2 | (16/61) | 71.8 | (61/85) | 40.0 | (16/40) | 57.5 | (61/106) | 1.0 | 1.0 | |
At M12 | 126 | ||||||||||||||
VL ≥ 1000 cp /mL | 23.8 | (30) | |||||||||||||
≥ 1 current missed (A) | 11.1 | (14) | 53.8 | 0.260 | 16.7 | (5/30) | 90.6 | (87/96) | 35.7 | (5/14) | 77.7 | (87/112) | 1.8 | 0.9 | |
≥ 2 cumulative missed (B) | 23.8 | (30) | 64.2 | 0.005 | 63.3 | (19/30) | 67.7 | (65/96) | 38.0 | (19/50) | 85.5 | (65/76) | 2.0 | 0.5 | |
A or B | 63.3 | (19/30) | 65.6 | (63/96) | 36.5 | (19/52) | 85.1 | (63/74) | 1.8 | 0.6 | |||||
A and B | 16.7 | (5/30) | 89.6 | (86/96) | 41.7 | (5/12) | 78.1 | (89/114) | 2.3 | 1.0 | |||||
At M24 | 79 | ||||||||||||||
VL > 400 cp /mL | 27.8 | (22) | |||||||||||||
≥ 1 current missed (A) | 13.9 | (11) | 56.6 | 0.100 | 22.7 | (5/22) | 89.5 | (51/57) | 45.5 | (5/11) | 75.0 | (51/68) | 2.2 | 0.9 | |
≥ 8 cumulative missed (B) | 62.0 | (49) | 57.7 | 0.130 | 72.7 | (16/22) | 42.1 | (24/57) | 32.7 | (16/49) | 80.0 | (24/30) | 1.3 | 0.7 | |
A or B | 72.7 | (16/22) | 40.4 | (23/57) | 32.0 | (16/50) | 79.3 | (23/29) | 1.2 | 0.7 | |||||
A and B | 22.7 | (5/22) | 91.2 | (52/57) | 50.0 | (5/10) | 75.4 | (52/69) | 2.6 | 0.9 | |||||
3b Children accompanied by mothers | AUC | Sensitivity | Specificity | PPV | NPV | LR+ | LR− | ||||||||
N | % | n | % | p | % | (n/N) | % | (n/N) | % | (n/N) | % | (n/N) | |||
At M3 | 116 | ||||||||||||||
VL ≥ 1000 cp /mL | 41.4 | (48) | |||||||||||||
≥ 1 current missed (A) | 25.0 | (29) | 49.9 | 0.510 | 21.7 | (12/48) | 72.6 | (51/68) | 41.4 | (12/29) | 58.6 | (51/87) | 1.0 | 1.0 | |
At M12 | |||||||||||||||
VL ≥ 1000 cp /mL | 92 | 22.8 | (21) | ||||||||||||
≥ 1 current missed (A) | 92 | 13.0 | (13) | 50.7 | 0.120 | 14.3 | (3/21) | 87.3 | (62/71) | 25.0 | (3/12) | 77.5 | (62/80) | 1.1 | 1.0 |
≥2 cumulative missed (B) | 67 | 30.4 | (21) | 68.1 | 0.010 | 64.3 | (9/14) | 77.4 | (43/55) | 42.9 | (9/21) | 89.6 | (43/48) | 3.0 | 0.5 |
A or B | 92 | 76.2 | 16/21) | 57.8 | (41/71) | 34.8 | (16/46) | 89.1 | (41/46) | 1.8 | 0.4 | ||||
A and B | 92 | 14.3 | (3/21) | 95.8 | (68/71) | 50.0 | (3/6) | 79.1 | (68/86) | 3.4 | 0.9 | ||||
At M24 | |||||||||||||||
VL > 400 cp /mL | 53 | 24.5 | (13) | ||||||||||||
≥ 1 current missed (A) | 53 | 9.4 | (5) | 51.4 | 0.410 | 7.7 | (1/13) | 90.0 | (36/40) | 20.0 | (1/5) | 75.0 | (36/48) | 0.8 | 1.0 |
≥ 8 cumulative missed (B) | 4 | 0 | (0) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
A or B | 53 | 100 | (13/13) | 5.0 | (2/40) | 25.5 | 13/51 | 100 | (2/2) | 1.1 | 0.0 | ||||
A and B | 4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||||