CFS patients
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Persisting or constantly relapsing fatigue lasting 3 months or more.
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Another current disease process or demanding life event that might explain the fatigue
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Functional disability resulting from fatigue to a degree that prevent normal school attendance
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Another chronic disease
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Age ≥ 12 years and < 18 years
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Permanent use of drugs (including hormones) possibly interfering with measurements
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Permanently bed-ridden
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Positive pregnancy test
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Pheocromocytoma
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Evidence of reduced cerebral and/or peripheral circulation due to vessel disease
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Polyneuropathy
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Renal insufficiency
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Known hypersensitivity towards clonidine or inert substances (lactose, saccarose) in capsule
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Abnormal ECG (apart from ectopic beats)
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Supine heart rate < 50 beats/min
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Supine systolic blood pressure < 85 mmHg
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Upright systolic blood pressure fall > 30 mmHg
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Healthy control subjects
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Age ≥ 12 years and < 18 years
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Another chronic disease
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Permanent use of drugs (including hormones)
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