U-shaped relationship between early blood glucose and mortality in critically ill children

BMC Pediatrics

Table 4 Association of PICU mortality with early hyperglycemia and hypoglycemia, stratified by PRISM III score: comparison to children with mean blood glucose of 110 to 140 mg/dL*

	Mean glucose, mg/dL (mmol/L)	OR	95 % CI	P value
PRISM III <10	>200 (11.1)^a	4.17	1.58–11.02	0.005
	140–200 (7.8–11.1)^b	2.13	0.84–5.43	0.115
	110–140 (6.1–7.8)	1		N.A.
	90–110 (5.0–6.1)	1.48	0.53–4.14	0.599
	60–90 (3.6–5.0)	1.80	0.56–5.79	0.338
	≤65 (3.6)^c	14.67	4.46–48.19	<0.001
PRISM III ≥10	>200 (11.1)^a	5.14	2.04–12.98	<0.001
	140–200 (7.8–11.1)^b	2.05	0.75–5.66	0.217
	110–140 (6.1–7.8)	1		N.A.
	90–110 (5.0–6.1)	1.36	0.35–5.29	0.725
	60–90 (3.6–5.0)	3.02	0.78–11.73	0.133
	≤65 (3.6)^c	8.69	2.19–34.45	0.002

*The mean glucose concentration of the first 24 h of admission >140 mg/dL was defined as early hyperglycemia; mean glucose concentration ≤65 mg/dL was defined as early hypoglycemia
Glucose strata were coded as a categorical variable with the mean glucose concentration of 110–140 mg/dL as a reference
CI confidence interval, OR odds ratio, PICU pediatric intensive care unit, PRISM III pediatric risk of mortality III
^asevere hyperglycemia. ^bmild hyperglycemia. ^chypoglycemia

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