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Table 3 Association of PICU mortality with early hyperglycemia and hypoglycemia: comparison to children with mean blood glucose of 110 to 140 mg/dL*

From: U-shaped relationship between early blood glucose and mortality in critically ill children

Mean Glucose, mg/dL (mmol/L)

ORa

95 % CI

P value

>200 (11.1)a

7.86

4.21–14.66

<0.001d

140–200 (7.8–11.1)b

2.25

1.17–4.36

0.016e

110–140 (6.1–7.8)

1

 

N.A.

90–110 (5.0–6.1)

1.37

0.64–2.92

0.416

65–90 (3.6–5.0)

1.90

0.82–4.38

0.133

≤65 (3.6)c

15.13

6.45–35.49

<0.001d

  1. *The mean glucose concentration of the first 24 h of admission >140 mg/dL was defined as early hyperglycemia; mean glucose concentration ≤65 mg/dL was defined as early hypoglycemia
  2. Glucose strata were coded as a categorical variable with the mean glucose concentration of 110–140 mg/dL as a reference
  3. CI confidence interval, OR odds ratio, PICU pediatric intensive care unit
  4. asevere hyperglycemia. bmild hyperglycemia. chypoglycemia. dThe association remained significant after adjusting for age, gender, and PRISM III scores. eThe association did not remain significant after adjusting for age, gender, and PRISM III scores