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Table 5 Odds ratio for factors associated with ADEs among children hospitalized in Jimma University Specialized Hospital

From: Adverse drug events in hospitalized children at Ethiopian University Hospital: a prospective observational study

Characteristics

ADEs occurred

Crude OR (95 % CI)

Adjusted ORb(95 % CI)

Yes (n = 46)

No (n = 588)

Number of medications ordereda

    

 1–5

34

512

1.0

1.0

 6–10

11

58

2.86 (1.37–5.94) **

0.76 (0.26–2.18)

 ≥11

1

3

5.02 (0.51–49.55)

0.17 (0.00–11.22)

Length of hospital stay

    

 1–8

12

352

1.0

1.0

 9–15

11

132

2.56 (1.10–5.95) **

2.47 (1.00–6.14)

 16–22

11

62

5.20 (2.20–12.32)*

5.06 (1.98–12.94) **

 ≥23

12

42

8.38 (3.54–19.84) *

8.04 (2.93–22.04) *

Age (Years)

    

 Neonate

4

94

1.0

1.0

 Infant

16

199

1.89 (0.61–5.81)

1.29 (0.39–4.23)

 Toddler

6

120

1.17 (0.32–4.28)

0.39 (0.09–1.74)

 Pre-school age

1

68

0.36 (0.04–3.16)

0.18 (0.02–1.87)

 School age

11

70

3.69 (1.13–12.08) **

1.94 (0.53–7.12)

 Adolescent

8

37

5.08 (1.44–17.90) **

2.69 (0.67–10.74)

Use of CNS medicines

    

 No

24

155

1.0

1.0

 Yes

22

433

2.56 (1.40–4.70) **

2.09 (1.01–4.32) **

Use of endocrine medicines

    

 No

35

537

1.0

1.0

 Yes

11

51

3.31 (1.58–6.91) **

3.38 (1.40–8.15) **

Use of other medicines

    

 No

42

572

1.0

1.0

 Yes

4

16

3.40 (1.09–10.64) **

1.79 (0.37–8.65)

Use of anti-histamine and anti-allergic

    

 No

40

584

1.0

1.0

 Yes

6

4

21.90 (5.94–80.80)*

32.51 (5.99–176.45)*

Presence of infectious disease

    

 No

5

185

1.0

1.0

 Yes

41

403

3.76 (1.46–9.68) **

3.43 (1.19–9.91) **

  1. * p < 0.001, **p < 0.05
  2. a15 patient admissions were not taking any medications. N = 619, ‘Yes’ = 46; ‘No’ = 573
  3. bThe odds ratio was adjusted for number of medications, length of hospital stay, age (years), use of CNS medicines, use of endocrine medicines, use of other medicines, use of antihistamine and anti-allergic and presence of infectious disease