Skip to main content

Table 5 Odds ratio for factors associated with ADEs among children hospitalized in Jimma University Specialized Hospital

From: Adverse drug events in hospitalized children at Ethiopian University Hospital: a prospective observational study

Characteristics ADEs occurred Crude OR (95 % CI) Adjusted ORb(95 % CI)
Yes (n = 46) No (n = 588)
Number of medications ordereda     
 1–5 34 512 1.0 1.0
 6–10 11 58 2.86 (1.37–5.94) ** 0.76 (0.26–2.18)
 ≥11 1 3 5.02 (0.51–49.55) 0.17 (0.00–11.22)
Length of hospital stay     
 1–8 12 352 1.0 1.0
 9–15 11 132 2.56 (1.10–5.95) ** 2.47 (1.00–6.14)
 16–22 11 62 5.20 (2.20–12.32)* 5.06 (1.98–12.94) **
 ≥23 12 42 8.38 (3.54–19.84) * 8.04 (2.93–22.04) *
Age (Years)     
 Neonate 4 94 1.0 1.0
 Infant 16 199 1.89 (0.61–5.81) 1.29 (0.39–4.23)
 Toddler 6 120 1.17 (0.32–4.28) 0.39 (0.09–1.74)
 Pre-school age 1 68 0.36 (0.04–3.16) 0.18 (0.02–1.87)
 School age 11 70 3.69 (1.13–12.08) ** 1.94 (0.53–7.12)
 Adolescent 8 37 5.08 (1.44–17.90) ** 2.69 (0.67–10.74)
Use of CNS medicines     
 No 24 155 1.0 1.0
 Yes 22 433 2.56 (1.40–4.70) ** 2.09 (1.01–4.32) **
Use of endocrine medicines     
 No 35 537 1.0 1.0
 Yes 11 51 3.31 (1.58–6.91) ** 3.38 (1.40–8.15) **
Use of other medicines     
 No 42 572 1.0 1.0
 Yes 4 16 3.40 (1.09–10.64) ** 1.79 (0.37–8.65)
Use of anti-histamine and anti-allergic     
 No 40 584 1.0 1.0
 Yes 6 4 21.90 (5.94–80.80)* 32.51 (5.99–176.45)*
Presence of infectious disease     
 No 5 185 1.0 1.0
 Yes 41 403 3.76 (1.46–9.68) ** 3.43 (1.19–9.91) **
  1. * p < 0.001, **p < 0.05
  2. a15 patient admissions were not taking any medications. N = 619, ‘Yes’ = 46; ‘No’ = 573
  3. bThe odds ratio was adjusted for number of medications, length of hospital stay, age (years), use of CNS medicines, use of endocrine medicines, use of other medicines, use of antihistamine and anti-allergic and presence of infectious disease