|
Fever
|
Unfavorable
|
Low specificity for identifying children who will not fail treatment
|
High feasibility since already implemented and measurement tools simple
|
|
Rapid breathing
|
Minimally favorable
|
Normal range highly variable
|
Measurement tools inaccurate
|
|
Low sensitivity for hypoxemic children
|
Low feasibility with respect to sequential monitoring of respiratory rates over time
|
|
Performance profile improves with sequential monitoring of respiratory rates over time
| |
|
Lower chest wall indrawing
|
Favorable
|
Low specificity for identifying children who will not fail treatment
|
Subjective sign with variable inter-provider agreement levels
|
|
Abnormal oxygen saturation
|
Highly favorable
|
High specificity for identifying children who will not fail treatment
|
Objective measurement but inter-provider agreement levels unknown
|
|
Later indicator decreases sensitivity for identifying children who will fail treatment at the community-level
|
Robust, precise, low-cost point-of-care instrument needed
|
| |
Likely costly to implement and sustain
|
|
High blood lactate levels
|
Unfavorable
|
Low specificity for identifying children who will not fail treatment
|
Point-of-care tool appropriate for community use not available, likely costly
|
|
Very late indicator decreases sensitivity for identifying children who will fail treatment at the community-level
| |
|
Moderate malnutrition
|
Highly favorable
|
Mid-range sensitivity and specificity which likely improves greatly in combination with other indicators
|
High feasibility since measurement tools simple and accurate
|
|
High positive predictive value
| |
|
HIV-affected
|
Minimally favorable
|
Geographically limited in relevancy (e.g. primarily in eastern and southern Africa)
|
Low feasibility since difficult to obtain HIV status at community-level (e.g. stigma)
|
|
High positive predictive value
| |
