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Table 2 The protocol of treatment with phenobarbital

From: Phenobarbital versus morphine in the management of neonatal abstinence syndrome, a randomized control trial

Initial loading dose of 20 mg/kg IV or IM If the symptoms persisted another 5 mg/kg was given q 8–12 h (the maximum loading dose = 40 mg/kg)

Loading dose (mg/kg)

Maintenance dose (mg/kg/24 h)

20

5

30

6

40

8

Continued until Finnegan score remained below 8 for 72 h then The drug was weaned gradually by 10 % of maximal dose every day until it was entirely discontinued