Skip to main content

Table 1 The dosing of frequently used beta-lactam antibiotics in European NICUs

From: High variability in the dosing of commonly used antibiotics revealed by a Europe-wide point prevalence study: implications for research and dissemination

Drug PNA group No of cases Unit dose (mg/kg/dose)    Dosing interval (h)  
    Current study; median (quartiles) Current study; range BNFC/Blue book Neofax Current study; median (quartiles) BNFC/the Blue book Neofax
Penicillin G 0–7 days 62 47 (27–53) 10–147 25 (50)*# 15–30 (45–60)* 12 (12–12) 12 12
N = 88 8–28 days 21 33 (31–50) 25–61 25 (50)*# 15–30 (45–60)* 12 (12–12) 8 8–12
  >28 days 5 40 (30–43) 28–43 25 (50)*# 15–30 (45–60)* 12 (10–12) 6 (4) 6–8
Ampicillin 0–7 days 69 52 (50–78) 24–126 30 (60; max 62.5)* 25–50 12 (12–12) 12 12
N = 82 8–21 days 6 52 (49–96) 47–96 30 (60; max 62.5)* 25–50 8 (8–12) 8 8–12
  22–28 days 4 47 (37–86) 34–99 30 (60; max 62.5)* 25–50 12 (8–12) 6 8–12
  >28 days 3 48 (45–69) 45–69 62.5 25–50 12 (8–12) 6 6–8
Cefotaxime 0–7 days 16 46 (29–51) 10–54 25 (50)* 50 12 (12–12) 12 12
N = 32 8–21 days 12 48 (25–50) 13–53 25 (50)* 50 8 (8–12) 8 8–12
  >21 days 4 47 (16–49) 5–49 25 (50)* 50 8 (8–8) 6–8 8–12
Ceftazidime 0–7 days 6 30 (25–41) 22–53 25 (50)*& 30 12 (8–12) 24 12
N = 20 8–21 days 5 43 (32–47) 27–49 25 (50)* 30 12 (8–12) 12 8–12
  >21 days 9 36 (30–39) 24–47   30 8 (8–12) 8 8–12
Meropenem 0–7 days 10 20 (19–22) 9–39 20 (40)* 20–40* 12 (8–12) 12 12
N = 20 8–28 days 10 21 (15–30) 9–43 20 (40)* 20–40* 10 (8–12) 8 8–12
  1. * – the dose in parentheses is recommended for severe infections and/or meningitis.
  2. # – for meningitis 75 mg/kg recommended in the Blue Book.
  3. & – only the higher dose of 50 mg/kg recommended by the Blue Book.
  4. PNA – postnatal age; BNFC – British National Formulary for Children.
  5. The number of prescriptions with accurate dosing data available is shown for each antibiotic. Data are shown as median and quartiles.