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Table 3 PROP Noninvasive respiratory assessments (NIRA) and relationship to physiologic measures

From: Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study of respiratory outcomes of preterm infants in the United States

NIRA Measurements Potential mechanism
Respiratory Inductance Plethysmography Tidal breathing analysis Altered lung compliance and airway obstruction
- Phase angle
- Tpef/Te
  Desaturations after short apnea Reduced functional residual capacity
  Response to inhaled albuterol Increased smooth muscle tone
- Phase angle
- Tpef/Te
Physiologic Challenges Oxygen and flow reduction to ambient air Alveolar-arterial oxygen gradient, control of breathing, standard definition of “BPD”
  Hypoxic challenge test with 0.15 FiO2 V/Q mismatch, control of breathing, “respiratory reserve”