Table 4 Comparison of immunization effects on extrauterine prevention alone for newborns of HBsAg- and/or HBeAg-positive women &
Pregnancy infection status | Newborn infection status | Detective time | Number of included studies | Sample size | Meta-RR (95% CI) |
|---|---|---|---|---|---|
Total (HBsAg+ and/or HBeAg+) | HBsAg+ | At birth | 7 | 1061 | 0.66(0.52,0.84) 3) |
7-12 month | 12 | 1451 | 0.54(0.42,0.69) 3) | ||
>12 month | 7 | 1214 | 0.54(0.42,0.69) 3) | ||
HBsAb+ | At birth | 4 | 291 | 2.12(1.66,2.70) 3) | |
7-12 month | 8 | 566 | 1.12(1.03,1.22) 3) | ||
>12 month | 5 | 502 | 1.06(0.96,1.16)3) | ||
Subgroup (HBsAg+ and HBeAg+) | HBsAg+ | At birth | 7 | 782 | 0.75(0.57,0.99) 3) |
7-12 month | 12 | 1095 | 0.56(0.42,0.75) 3) | ||
>12 month | 7 | 889 | 0.55(0.41,0.75) 3) | ||
HBsAb+ | At birth | 4 | 291 | 3.25(1.35,7.83) 2) | |
7-12 month | 9 | 443 | 1.14(1.05,1.24) 3) | ||
>12 month | 5 | 502 | 1.06(0.96,1.16)3) | ||
Subgroup (HBsAg+ and HBeAg-) | HBsAg+ | At birth | 1 | 279 | 0.59(0.34,1.02)3) |
7-12 month | 3 | 356 | 0.64(0.39,1.06)3) | ||
>12 month | 2 | 325 | 0.63(0.41,0.97) 3) | ||
Subgroup (low + unclear bias) | HBsAg+ | At birth | 4 | 348 | 0.82(0.58,1.18)3) |
7-12 month | 10 | 739 | 0.56(0.38,0.82) 3) | ||
>12 month | 4 | 400 | 0.43(0.23,0.82) 3) | ||
HBsAb+ | At birth | 3 | 221 | 4.21(2.70,6.57) 3) | |
7-12 month | 8 | 566 | 1.12(1.03,1.22) 3) | ||
>12 month | 4 | 400 | 1.05(0.93,1.17)3) | ||
Subgroup (high risk bias) | HBsAg+ | At birth | 3 | 713 | 0.58(0.42,0.81) 3) |
7-12 month | 2 | 712 | 0.53(0.39,0.72) 3) | ||
>12 month | 3 | 814 | 0.56(0.43,0.73) 3) | ||
HBsAb+ | At birth | 1 | 70 | 0.91(0.76,1.09) | |
7-12 month | - | - | - | ||
>12 month | 1 | 102 | 1.09(0.93,1.27) |