|
Pregnancy infection status
|
Newborn infection status
|
Detective time
|
Number of included studies
|
Sample size
|
Meta-RR (95% CI)
|
|---|
|
Total (HBsAg+ and/or HBeAg+)
|
HBsAg+
|
At birth
|
7
|
1061
|
0.66(0.52,0.84)
3)
|
|
7-12 month
|
12
|
1451
|
0.54(0.42,0.69)
3)
|
|
>12 month
|
7
|
1214
|
0.54(0.42,0.69)
3)
|
|
HBsAb+
|
At birth
|
4
|
291
|
2.12(1.66,2.70)
3)
|
|
7-12 month
|
8
|
566
|
1.12(1.03,1.22)
3)
|
|
>12 month
|
5
|
502
|
1.06(0.96,1.16)3)
|
|
Subgroup (HBsAg+ and HBeAg+)
|
HBsAg+
|
At birth
|
7
|
782
|
0.75(0.57,0.99)
3)
|
|
7-12 month
|
12
|
1095
|
0.56(0.42,0.75)
3)
|
|
>12 month
|
7
|
889
|
0.55(0.41,0.75)
3)
|
|
HBsAb+
|
At birth
|
4
|
291
|
3.25(1.35,7.83)
2)
|
|
7-12 month
|
9
|
443
|
1.14(1.05,1.24)
3)
|
|
>12 month
|
5
|
502
|
1.06(0.96,1.16)3)
|
|
Subgroup (HBsAg+ and HBeAg-)
|
HBsAg+
|
At birth
|
1
|
279
|
0.59(0.34,1.02)3)
|
|
7-12 month
|
3
|
356
|
0.64(0.39,1.06)3)
|
|
>12 month
|
2
|
325
|
0.63(0.41,0.97)
3)
|
|
Subgroup (low + unclear bias)
|
HBsAg+
|
At birth
|
4
|
348
|
0.82(0.58,1.18)3)
|
|
7-12 month
|
10
|
739
|
0.56(0.38,0.82)
3)
|
|
>12 month
|
4
|
400
|
0.43(0.23,0.82)
3)
|
|
HBsAb+
|
At birth
|
3
|
221
|
4.21(2.70,6.57)
3)
|
|
7-12 month
|
8
|
566
|
1.12(1.03,1.22)
3)
|
|
>12 month
|
4
|
400
|
1.05(0.93,1.17)3)
|
|
Subgroup (high risk bias)
|
HBsAg+
|
At birth
|
3
|
713
|
0.58(0.42,0.81)
3)
|
|
7-12 month
|
2
|
712
|
0.53(0.39,0.72)
3)
|
|
>12 month
|
3
|
814
|
0.56(0.43,0.73)
3)
|
|
HBsAb+
|
At birth
|
1
|
70
|
0.91(0.76,1.09)
|
|
7-12 month
|
-
|
-
|
-
|
|
>12 month
|
1
|
102
|
1.09(0.93,1.27)
|
-
&(Mother: none/Infants: HBIG + vaccine) vs (Mother: none/Infants: vaccine); 2)Random effects model, inverse variance method; 3)Fixed effects model, Mantel-Haenszel method; values in boldface indicate statistical significance (P < 0.05).
