Table 3 Comparison of immunization effects on intrauterine and extrauterine prevention in newborns of HBsAg- and/or HBeAg-positive women 1)
Pregnancy infection status | Newborn infection status | Detective time | Number of included studies | Sample size | Meta-RR (95% CI) |
|---|---|---|---|---|---|
Total (HBsAg+ and/or HBeAg+) | HBsAg+ | At birth | 23 | 4274 | 0.36(0.28, 0.45) 2) |
7-12 month | 8 | 1036 | 0.34(0.22, 0.53) 2) | ||
>12 month | 1 | 153 | 0.33(0.01, 7.95)2) | ||
HBsAb+ | At birth | 7 | 1094 | 2.42(1.46, 4.01) 2) | |
7-12 month | 6 | 757 | 1.12(1.00, 1.24)2) | ||
>12 month | 1 | 153 | 1.07(0.86, 1.33)2) | ||
Subgroup (HBsAg+ and HBeAg+) | HBsAg+ | At birth | 21 | 2159 | 0.40(0.32, 0.51) 2) |
7-12 month | 8 | 812 | 0.37(0.23, 0.57) 3) | ||
>12 month | 1 | 153 | 0.33(0.01, 7.95)2) | ||
HBsAb+ | At birth | 7 | 909 | 3.05(2.19, 4.25) 2) | |
7-12 month | 6 | 614 | 1.15(0.99, 1.34)2) | ||
>12 month | 1 | 153 | 1.07(0.86, 1.33)2) | ||
Subgroup (HBsAg+ and HBeAg-) | HBsAg+ | At birth | 15 | 1892 | 0.22(0.14, 0.35) 3) |
7-12 month | 4 | 224 | 0.22(0.06, 0.84) 3) | ||
HBsAb+ | At birth | 3 | 185 | 1.31(0.82, 2.10)3) | |
7-12 month | 3 | 148 | 1.09(0.97, 1.22)3) | ||
Subgroup (low+unclear bias) | HBsAg+ | At birth | 12 | 1945 | 0.35(0.22,0.54) 2) |
7-12 month | 5 | 643 | 0.52(0.30,0.91) 3) | ||
>12 month | 1 | 153 | 0.33(0.01,7.95)3) | ||
HBsAb+ | At birth | 6 | 980 | 3.02(1.48,6.15) 2) | |
7-12 month | 5 | 643 | 1.04(0.98,1.10)3) | ||
>12 month | 1 | 153 | 1.07(0.86,1.33)3) | ||
Subgroup (high risk bias) | HBsAg+ | At birth | 11 | 2329 | 0.37(0.29,0.47) 3) |
7-12 month | 3 | 393 | 0.18(0.08,0.39) 3) | ||
HBsAb+ | At birth | 1 | 114 | 1.60(1.26,2.03) 3) | |
7-12 month | 1 | 114 | 1.49(1.23,1.81) 2) |