|
Pregnancy infection status
|
Newborn infection status
|
Detective time
|
Number of included studies
|
Sample size
|
Meta-RR (95% CI)
|
|---|
|
Total (HBsAg+ and/or HBeAg+)
|
HBsAg+
|
At birth
|
23
|
4274
|
0.36(0.28, 0.45)
2)
|
|
7-12 month
|
8
|
1036
|
0.34(0.22, 0.53)
2)
|
|
>12 month
|
1
|
153
|
0.33(0.01, 7.95)2)
|
|
HBsAb+
|
At birth
|
7
|
1094
|
2.42(1.46, 4.01)
2)
|
|
7-12 month
|
6
|
757
|
1.12(1.00, 1.24)2)
|
|
>12 month
|
1
|
153
|
1.07(0.86, 1.33)2)
|
|
Subgroup (HBsAg+ and HBeAg+)
|
HBsAg+
|
At birth
|
21
|
2159
|
0.40(0.32, 0.51)
2)
|
|
7-12 month
|
8
|
812
|
0.37(0.23, 0.57)
3)
|
|
>12 month
|
1
|
153
|
0.33(0.01, 7.95)2)
|
|
HBsAb+
|
At birth
|
7
|
909
|
3.05(2.19, 4.25)
2)
|
|
7-12 month
|
6
|
614
|
1.15(0.99, 1.34)2)
|
|
>12 month
|
1
|
153
|
1.07(0.86, 1.33)2)
|
|
Subgroup (HBsAg+ and HBeAg-)
|
HBsAg+
|
At birth
|
15
|
1892
|
0.22(0.14, 0.35)
3)
|
|
7-12 month
|
4
|
224
|
0.22(0.06, 0.84)
3)
|
|
HBsAb+
|
At birth
|
3
|
185
|
1.31(0.82, 2.10)3)
|
|
7-12 month
|
3
|
148
|
1.09(0.97, 1.22)3)
|
|
Subgroup (low+unclear bias)
|
HBsAg+
|
At birth
|
12
|
1945
|
0.35(0.22,0.54)
2)
|
|
7-12 month
|
5
|
643
|
0.52(0.30,0.91)
3)
|
|
>12 month
|
1
|
153
|
0.33(0.01,7.95)3)
|
|
HBsAb+
|
At birth
|
6
|
980
|
3.02(1.48,6.15)
2)
|
|
7-12 month
|
5
|
643
|
1.04(0.98,1.10)3)
|
|
>12 month
|
1
|
153
|
1.07(0.86,1.33)3)
|
|
Subgroup (high risk bias)
|
HBsAg+
|
At birth
|
11
|
2329
|
0.37(0.29,0.47)
3)
|
|
7-12 month
|
3
|
393
|
0.18(0.08,0.39)
3)
|
|
HBsAb+
|
At birth
|
1
|
114
|
1.60(1.26,2.03)
3)
|
|
7-12 month
|
1
|
114
|
1.49(1.23,1.81)
2)
|
-
1)(Mother: HBIG/Infants: HBIG + vaccine) vs (Mother: none/Infants: HBIG + vaccine); 2)Random effects model, inverse variance method; 3)Fixed effects model, Mantel-Haenszel method; values in boldface indicate statistical significance (P < 0.05).
