Table 1 Summary of Included studies
From: The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects
Study citation | Inclusion criteria | # of patients | Age range of patients | Diagnostic criteria | Patient source | Country of origin |
|---|---|---|---|---|---|---|
Kapur et. al (2012) [9] | Children < 18 years | 113 | 3-195 months | HRCT scan | Single children’s hospital | Australia |
HRCT scan diagnosis of bronchiectasis | ||||||
Availability of BAL fluid cytology | ||||||
Microbiological results from bronchoscopy | ||||||
No CF diagnosis | ||||||
Zaid et. al (2010) [17] | Children < 18 years with discharge diagnosis of chronic bronchitis, bronchiectasis, or chronic suppurative lung disease | 92 | 1.5-13 years | HRCT scan Clinical diagnosis | All Irish public hospitals’ discharge data | Ireland |
Verified with chart review, exclusion of CF and radiology review of HRCT | ||||||
No CF diagnosis (sweat chloride < 60) | ||||||
Karakoc et. al (2009) [11] | Diagnosis of bronchiectasis based on suggestive clinical and radiological features confirmed by HRCT | 22 | 87.0 +/− 56.85 months [1] | HRCT scan and clinical diagnosis | Dept of Allergy and Immunology at University Center | Turkey |
Banjar (2007) [6] | Non-CF bronchiectasis based on CXR and/or CT chest | 151 | 7.3 +/− 4.1 years | CXR | Single center | Saudi Arabia |
CT chest (96%) | ||||||
Li et. al (2005) [13] | Database search bronchiectasis, chronic suppurative lung disease, and chronic cough | 136 | 3.1-18.1 years [2] | HRCT scan | Two centers | United Kingdom |
HRCT diagnosed bronchiectasis with suggestive clinical feature | ||||||
No CF diagnosis (sweat test, genetic mutations, nasal potential differences and faecal elastase if equivocal) | ||||||
Karadag et. al (2005) [10] | Patients with non-CF bronchiectasis confirmed with HRCT | 111 | 7.4 +/− 3.7 years | HRCT scan | Single center | Turkey |
Eastham et. al (2004) [7] | Children with bronchiectasis confirmed with HRCT | 93 | 1.6-18.8 years | HRCT scan | Single center | United Kingdom |
Munro et. al (2011) [14] | All children had HRCT and had at least 5 years of follow up | 91 | 0.9-16 years | HRCT scan | Database of single children’s hospital | New Zealand |
Series of investigations to exclude CF and identify the presumed etiology for bronchiectasis | ||||||
Singleton et. al (2000) [16] | Assessed by a pediatric pulmonologist to have definite (CT findings) bronchiectasis [3] | 28 | 1-15 years | HRCT | Two centers | Alaska |
Gaillard et. al (2003) [8] | Database search identifying children with 2 or more HRCT scans of the lungs in whom bronchiectasis was reported in the first scan, then reviewed by a single consultant radiologist | 22 | 1-16 years [4] | HRCT | Single children’s hospital | United Kingdom |
Exclusion of CF patients | ||||||
Koh et. al (1997) [12] | Clinical features of bronchiectasis conformed by CT and by bronchoscopy when necessary | 25 | 13.1 +/− 2.6 years [2] | Clinical plus CT | Single clinic | Korea |
Santamaria et. al (2008) [15] | Bronchiectasis identified by HRCT | 105 | 0-14.4 years | HRCT | Two centers | Italy |