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Table 6 Reporting of Interim Analysis Parameters in trials that mentioned Interim Analysis (n = 62)

From: A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials

Parameter Pediatric Journals (n = 22) General Journals (n = 40)
Number of formal interim analyses planned   
   Reported 8 (36) 23 (58)
   Unclear or Not Reported 14 (64) 17 (42)
Number of formal interim analyses performed   
   Reported 19 (86) 33 (83)
   Unclear or Not Reported 3 (14) 7 (17)
Parameter defining timing of interim   
   Reported 18 (82) 30 (75)
   Unclear or Not Reported 4 (18) 10 (25)
Outcomes on which interim analyses were performed   
   Reported 13 (59) 32 (80)
   Unclear or Not Reported 9 (41) 8 (20)
Statistical monitoring methods specified   
   Reported 11 (50) 22 (55)
   Unclear or Not Reported 11 (50) 18 (45)
Adjustment of results for interim analysis (p value, CI or estimate)   
   Reported 2 (9) 17 (43)
   Unclear or Not Reported 20 (91) 23 (57)
  1. N (%)