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Table 4 Multiple logistic regression analysis of clinical and laboratory variables predicting failure of empiric antibiotic regimen at 24 and 72 hours of age

From: Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis

 

OR (95% CI)

p-value

24 hour model (n = 232)

  

Need for vasoactive treatment

2.83 (1.21-6.66)

0.0167

WBC <5000 or >20000 per mm3 on Day 1

2.51 (1.09-5.81)

0.0308

I/T ratio >0.2 on Day 1

2.79 (1.10-7.11)

0.0312

Platelet count on Day 1 (per 10,000 mm-3 increase)

0.92 (0.86-0.98)

0.0124

72 hour model (n = 252)

  

Need for vasoactive treatment

4.43 (1.55-12.68)

0.0055

Platelet count on Day 2-3 (per 10,000 mm-3 increase)

0.92 (0.86-0.99)

0.0331

C-reactive protein (per 1 mg/l increase) on Day 1

1.02 (1.00-1.03)

0.0359

Serum albumin on Day 2-3 (per 1 g/L increase)

0.87 (0.80-0.95)

0.0029

  1. OR - odds ratio; 95% CI - 95% confidence interval; ICU - intensive care unit; WBC - white blood cell count; I/T ratio - immature to total neutrophil ratio