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Table 4 Multiple logistic regression analysis of clinical and laboratory variables predicting failure of empiric antibiotic regimen at 24 and 72 hours of age

From: Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis

  OR (95% CI) p-value
24 hour model (n = 232)   
Need for vasoactive treatment 2.83 (1.21-6.66) 0.0167
WBC <5000 or >20000 per mm3 on Day 1 2.51 (1.09-5.81) 0.0308
I/T ratio >0.2 on Day 1 2.79 (1.10-7.11) 0.0312
Platelet count on Day 1 (per 10,000 mm-3 increase) 0.92 (0.86-0.98) 0.0124
72 hour model (n = 252)   
Need for vasoactive treatment 4.43 (1.55-12.68) 0.0055
Platelet count on Day 2-3 (per 10,000 mm-3 increase) 0.92 (0.86-0.99) 0.0331
C-reactive protein (per 1 mg/l increase) on Day 1 1.02 (1.00-1.03) 0.0359
Serum albumin on Day 2-3 (per 1 g/L increase) 0.87 (0.80-0.95) 0.0029
  1. OR - odds ratio; 95% CI - 95% confidence interval; ICU - intensive care unit; WBC - white blood cell count; I/T ratio - immature to total neutrophil ratio