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Table 3 Significant predictors of empiric antibiotic failure: results of univariate logistic regression analysis

From: Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis

  OR (95% CI) p-value
Maternal and perinatal characteristics   
Maternal chorioamnionitis (yes vs. no) 2.76 (1.24-6.17) 0.0132
Maternal smoking during pregnancy (yes vs. no) 3.13 (1.05-9.38) 0.041
Isolation of a pathogen from maternal urinary tract; birth canal or placenta during delivery 6.39 (1.36-29.97) 0.0187
Neonatal characteristics   
1st minute Apgar score (per 1 point increase) 0.79 (0.66-0.95) 0.0124
Birthweight (per 100 g increase) 0.94 (0.89-0.98) 0.008
Gestational age (per week increase) 0.88 (0.81-0.96) 0.004
Age on admission to ICU (per hour increase) 0.84 (0.70-0.99) 0.0411
Number of vasoactive drugs (per 1 additional drug) 2.50 (1.76-3.54) 0.000
Intolerance of enteral feeds within 3 days 2.64 (1.17-5.92) 0.0188
Laboratory characteristics   
WBC <5000 or >20000 per mm3 on Day 1 3.42 (1.61-9.47) 0.0014
WBC <5000 or >20000 per mm3 on Day 2-3 2.84 (1.33-6.10) 0.0072
I/T ratio >0.2 on Day 1 3.90 (1.61-9.47) 0.0026
I/T ratio >0.2 on Day 2-3 4.25 (1.55-11.62) 0.0048
Platelet count on Day 1 (per 10,000 mm-3 increase) 0.89 (0.83-0.95) 0.0003
Platelet count on Day 2-3 (per 10,000 mm-3 increase) 0.86 (0.81-0.92) 0.0000
Haemoglobin on Day 2-3 (per 10 g/L increase) 0.72 (0.60-0.86) 0.0002
C-reactive protein > 10 mg/l on Day 1 3.34 (1.39-8.01) 0.007
C-reactive protein > 10 mg/l on Day 2-3 2.53 (1.17-5.45) 0.0179
Blood glucose < 3.0 mmol/l or >5.5 mmol/l on Day 1 4.28 (1.45-12.64) 0.0084
Blood glucose < 3.0 mmol/l or >5.5 mmol/l on Day 2-3 3.72 (1.55-8.97) 0.0034
Urea on Day 2-3 (per 1 mmol/L increase) 1.08 (1.00-1.16) 0.0411
Serum albumin on Day 2-3 (per 1 g/L increase) 0.82 (0.76-0.90) 0.0000
Serum AST on Day 2-3 (per 1 IU/L increase) 1.00 (1.00-1.00) 0.0231
  1. OR - odds ratio; 95% CI - 95% confidence interval; ICU - intensive care unit; WBC - white blood cell count; I/T ratio - immature to total neutrophil ratio; AST - aspartate aminotransferase