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Table 7 Comparison of HIV-infected women with CD4+ cell counts >500/μL to HIV-uninfected women

From: Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol

  HIV (+) CD4 > 500/µL HIV (-)  
Laboratory measures Mean N P2.75 P97.5 Mean N P2.75 P97.5 P value
Study visit at 20–24 weeks gestation
Red blood cells 106/μL 3.7 512 2.8 4.8 3.8 367 2.7 4.9 0.01
Hemoglobin g/dL 10.5 512 7.7 13 11.0 367 8.2 13.2 < .0001
Hematocrit % 30.9 512 21.5 38.5 32.3 367 23.8 39.4 < .0001
Platelets 103/μL 242.9 512 111 453 204.3 367 97 350 < .0001
White blood cells 103/μL 7.2 513 3.5 12.0 6.9 366 3.3 11.1 0.02
Lymphocytes % 33.7 506 20.1 60.1 31.5 358 19.0 57.0 0.0005
Monocytes % 7.7 506 1.2 21.2 6.8 358 1.9 17.0 0.008
Granulocytes % 58.2 506 21.5 73.4 61.7 358 28.6 77.5 < .0001
CD4+ cells/μL 670 515 504 1090 810 246 344 1366 < .0001
CD8+ cells/μL 893 515 364 1919 514 246 262 1002 < .0001
CD4 % 34.4 56 16 51 47.6 55 33 65 < .0001
CD8 % 48.1 56 28 71 31.7 55 18 50 < .0001
Total T-Lymphocytes as % of all lymphocytes 77.4 43 55 94 75.6 47 60 93 0.4
Study visit at 36 weeks gestation
Red blood cells 106/μL 3.9 422 2.9 5.0 3.9 280 2.9 5.3 0.3
Hemoglobin g/dl 11.0 422 8.4 13.2 11.3 280 9.0 14.0 0.003
Hematocrit % 32.7 422 23.6 40.0 33.3 280 25.9 41.9 0.06
Platelets 103/μL 212.2 422 104 382 183 280 87 345 < .0001
White blood cells 103/μL 7.1 421 4.3 11.0 6.7 280 3.8 11.2 0.01
Lymphocytes % 33.3 417 18.5 50.3 31.8 274 18.1 53.6 0.01
Monocytes % 7.9 417 1.9 19.1 7.5 274 1.1 23.1 0.4
Granulocytes % 58.7 417 33.8 74.2 60.7 274 32.6 76.5 0.02
CD4+ cells/μL 677 425 507 1155 786 166 368 1325 < .0001
CD8+ cells/μL 870 425 395 1639 507 166 216 1106 < .0001
CD4 % 35.2 33 16 53 45.0 49 28 66 < .0001
CD8 % 47.1 33 29 68 31.1 49 21 43 < .0001
Total T-Lymphocytes as % of all lymphocytes 79.3 28 60 91 74.1 43 54 90 0.02
  1. Laboratory values for pregnant women at the 20–24-week gestational age visit and at the 36-week visit. Of the 2633 women with data at baseline, 727 (27.6%) were missing week 36 data and 1906 (72.4%) had 36-week data. It is possible that week 36 women were slightly healthier than week 20–24 women, since the 36 week women had a slightly higher CD4+ cell count and may have been more likely to be able to keep the 36-week appointment (see discussion).
  2. Lower 95% confidence interval = P2.75 = 2.75%ile
  3. Upper 95% confidence interval = P97.5 = 97.5%ile