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Table 7 Comparison of HIV-infected women with CD4+ cell counts >500/μL to HIV-uninfected women

From: Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol

 

HIV (+) CD4 > 500/µL

HIV (-)

 

Laboratory measures

Mean

N

P2.75

P97.5

Mean

N

P2.75

P97.5

P value

Study visit at 20–24 weeks gestation

Red blood cells 106/μL

3.7

512

2.8

4.8

3.8

367

2.7

4.9

0.01

Hemoglobin g/dL

10.5

512

7.7

13

11.0

367

8.2

13.2

< .0001

Hematocrit %

30.9

512

21.5

38.5

32.3

367

23.8

39.4

< .0001

Platelets 103/μL

242.9

512

111

453

204.3

367

97

350

< .0001

White blood cells 103/μL

7.2

513

3.5

12.0

6.9

366

3.3

11.1

0.02

Lymphocytes %

33.7

506

20.1

60.1

31.5

358

19.0

57.0

0.0005

Monocytes %

7.7

506

1.2

21.2

6.8

358

1.9

17.0

0.008

Granulocytes %

58.2

506

21.5

73.4

61.7

358

28.6

77.5

< .0001

CD4+ cells/μL

670

515

504

1090

810

246

344

1366

< .0001

CD8+ cells/μL

893

515

364

1919

514

246

262

1002

< .0001

CD4 %

34.4

56

16

51

47.6

55

33

65

< .0001

CD8 %

48.1

56

28

71

31.7

55

18

50

< .0001

Total T-Lymphocytes as % of all lymphocytes

77.4

43

55

94

75.6

47

60

93

0.4

Study visit at 36 weeks gestation

Red blood cells 106/μL

3.9

422

2.9

5.0

3.9

280

2.9

5.3

0.3

Hemoglobin g/dl

11.0

422

8.4

13.2

11.3

280

9.0

14.0

0.003

Hematocrit %

32.7

422

23.6

40.0

33.3

280

25.9

41.9

0.06

Platelets 103/μL

212.2

422

104

382

183

280

87

345

< .0001

White blood cells 103/μL

7.1

421

4.3

11.0

6.7

280

3.8

11.2

0.01

Lymphocytes %

33.3

417

18.5

50.3

31.8

274

18.1

53.6

0.01

Monocytes %

7.9

417

1.9

19.1

7.5

274

1.1

23.1

0.4

Granulocytes %

58.7

417

33.8

74.2

60.7

274

32.6

76.5

0.02

CD4+ cells/μL

677

425

507

1155

786

166

368

1325

< .0001

CD8+ cells/μL

870

425

395

1639

507

166

216

1106

< .0001

CD4 %

35.2

33

16

53

45.0

49

28

66

< .0001

CD8 %

47.1

33

29

68

31.1

49

21

43

< .0001

Total T-Lymphocytes as % of all lymphocytes

79.3

28

60

91

74.1

43

54

90

0.02

  1. Laboratory values for pregnant women at the 20–24-week gestational age visit and at the 36-week visit. Of the 2633 women with data at baseline, 727 (27.6%) were missing week 36 data and 1906 (72.4%) had 36-week data. It is possible that week 36 women were slightly healthier than week 20–24 women, since the 36 week women had a slightly higher CD4+ cell count and may have been more likely to be able to keep the 36-week appointment (see discussion).
  2. Lower 95% confidence interval = P2.75 = 2.75%ile
  3. Upper 95% confidence interval = P97.5 = 97.5%ile
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