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Table 6 Comparison of HIV-infected women with CD4+ cell counts 350–500/μL to HIV-uninfected women

From: Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol

  HIV (+) CD4 350–500/μL HIV (-)  
Laboratory measures Mean N P2.75 P97.5 Mean N P2.75 P97.5 P value
Study visit at 20–24 weeks gestation
Red blood cells 106/μL 3.6 488 2.7 4.6 3.8 367 2.7 4.9 < .0001
Hemoglobin g/dL 10.3 486 7.1 12.7 11.0 367 8.2 13.2 < .0001
Hematocrit % 30.2 488 21.6 37.4 32.3 367 23.8 39.4 < .0001
Platelets 103/μL 227.8 488 103 399 204.3 367 97 350 < .0001
White blood cells 103/μL 6.2 488 2.8 9.5 6.9 366 3.3 11.1 < .0001
Lymphocytes % 32.2 481 19.0 62.5 31.5 358 19.0 57.0 0.3
Monocytes % 7.7 481 1.7 17.7 6.8 358 1.9 17.0 0.004
Granulocytes % 59.9 481 21.4 75.5 61.7 358 28.6 77.5 0.03
CD4+ cells/μL 418 489 352 495 810 246 344 1366 < .0001
CD8+ cells/μL 788 489 349 1602 514 246 262 1002 < .0001
CD4 % 28.6 49 17 52 47.6 55 33 65 < .0001
CD8 % 51.7 49 22 77 31.7 55 18 50 < .0001
Total T-Lymphocytes as % of all lymphocytes 77.0 40 46 96.5 75.6 47 60 93 0.5
Study visit at 36 weeks gestation
Red blood cells 106/μL 3.8 356 2.8 4.9 3.9 280 2.9 5.3 0.002
Hemoglobin g/dL 10.7 356 8 13.5 11.3 280 9 14.0 < .0001
Hematocrit % 31.7 356 23.3 40 33.3 280 25.9 41.9 < .0001
Platelets 103/μL 214.0 356 86 448 182.9 280 87 345 < .0001
White blood cells 103/μL 6.1 356 3.3 9.9 6.7 280 3.8 11.2 < .0001
Lymphocytes % 31.6 356 19.3 53.4 31.8 274 18.1 53.6 0.8
Monocytes % 8.6 356 2.5 23.5 7.5 274 1.1 23.1 0.01
Granulocytes % 59.6 356 29.5 75.0 60.7 274 32.6 76.5 0.2
CD4+ cells/μL 418 359 353 495 786 166 368 1325 < .0001
CD8+ cells/μL 779 359 340 1515 507 166 216 1106 < .0001
CD4 % 28.2 36 12 50 45.0 49 28 66 < .0001
CD8 % 51.8 36 20 76 31.1 49 21 43 < .0001
Total T-Lymphocytes as % of all lymphocytes 78.4 34 57 92 74.1 43 54 90 0.05
  1. Laboratory values for pregnant women at the 20–24-week gestational age visit and at the 36-week visit. Of the 2633 women with data at baseline, 727 (27.6%) were missing week 36 data and 1906 (72.4%) had 36-week data. It is possible that week 36 women were slightly healthier than week 20–24 women, since the 36 week women had a slightly higher CD4+ cell count and may have been more likely to be able to keep the 36-week appointment (see discussion).
  2. Lower 95% confidence interval = P2.75 = 2.75%ile
  3. Upper 95% confidence interval = P97.5 = 97.5%ile