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Table 6 Comparison of HIV-infected women with CD4+ cell counts 350–500/μL to HIV-uninfected women

From: Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV Prevention Trials Network 024 protocol

 

HIV (+) CD4 350–500/μL

HIV (-)

 

Laboratory measures

Mean

N

P2.75

P97.5

Mean

N

P2.75

P97.5

P value

Study visit at 20–24 weeks gestation

Red blood cells 106/μL

3.6

488

2.7

4.6

3.8

367

2.7

4.9

< .0001

Hemoglobin g/dL

10.3

486

7.1

12.7

11.0

367

8.2

13.2

< .0001

Hematocrit %

30.2

488

21.6

37.4

32.3

367

23.8

39.4

< .0001

Platelets 103/μL

227.8

488

103

399

204.3

367

97

350

< .0001

White blood cells 103/μL

6.2

488

2.8

9.5

6.9

366

3.3

11.1

< .0001

Lymphocytes %

32.2

481

19.0

62.5

31.5

358

19.0

57.0

0.3

Monocytes %

7.7

481

1.7

17.7

6.8

358

1.9

17.0

0.004

Granulocytes %

59.9

481

21.4

75.5

61.7

358

28.6

77.5

0.03

CD4+ cells/μL

418

489

352

495

810

246

344

1366

< .0001

CD8+ cells/μL

788

489

349

1602

514

246

262

1002

< .0001

CD4 %

28.6

49

17

52

47.6

55

33

65

< .0001

CD8 %

51.7

49

22

77

31.7

55

18

50

< .0001

Total T-Lymphocytes as % of all lymphocytes

77.0

40

46

96.5

75.6

47

60

93

0.5

Study visit at 36 weeks gestation

Red blood cells 106/μL

3.8

356

2.8

4.9

3.9

280

2.9

5.3

0.002

Hemoglobin g/dL

10.7

356

8

13.5

11.3

280

9

14.0

< .0001

Hematocrit %

31.7

356

23.3

40

33.3

280

25.9

41.9

< .0001

Platelets 103/μL

214.0

356

86

448

182.9

280

87

345

< .0001

White blood cells 103/μL

6.1

356

3.3

9.9

6.7

280

3.8

11.2

< .0001

Lymphocytes %

31.6

356

19.3

53.4

31.8

274

18.1

53.6

0.8

Monocytes %

8.6

356

2.5

23.5

7.5

274

1.1

23.1

0.01

Granulocytes %

59.6

356

29.5

75.0

60.7

274

32.6

76.5

0.2

CD4+ cells/μL

418

359

353

495

786

166

368

1325

< .0001

CD8+ cells/μL

779

359

340

1515

507

166

216

1106

< .0001

CD4 %

28.2

36

12

50

45.0

49

28

66

< .0001

CD8 %

51.8

36

20

76

31.1

49

21

43

< .0001

Total T-Lymphocytes as % of all lymphocytes

78.4

34

57

92

74.1

43

54

90

0.05

  1. Laboratory values for pregnant women at the 20–24-week gestational age visit and at the 36-week visit. Of the 2633 women with data at baseline, 727 (27.6%) were missing week 36 data and 1906 (72.4%) had 36-week data. It is possible that week 36 women were slightly healthier than week 20–24 women, since the 36 week women had a slightly higher CD4+ cell count and may have been more likely to be able to keep the 36-week appointment (see discussion).
  2. Lower 95% confidence interval = P2.75 = 2.75%ile
  3. Upper 95% confidence interval = P97.5 = 97.5%ile
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