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Table 4 Birth year adjusted analyses of the association between infant characteristics and childhood leukemia.

From: Parental and infant characteristics and childhood leukemia in Minnesota

  Sub-cohort ALL AML
  No. (%) No. (%) HR 95% CI No. (%) HR 95% CI
Child gender        
   female 4242 (49) 227 (41) ref. 43 (49) ref.
   male 4501 (51) 332 (59) 1.38 1.16–1.64 44 (51) 0.97 0.64–1.49
   missing 7 (0) 1 (0)    0 (0)   
Birth weight        
   Per 1 sd increase (per 581 grams) 8710 555 1.12 1.03–1.23 87 1.33 1.06–1.66
Birth weight category        
   < 2496 g 406 (5) 29 (5) 1.49 0.96–2.30 2 (2) 0.86 0.19–3.94
   2496–3117 g 1746 (20) 83 (15) ref. 10 (11) ref.
   3118–3458 g 2192 (25) 117 (21) 1.13 0.84–1.51 23 (26) 1.85 0.88–3.91
   3459–3798 g 2142 (25) 152 (27) 1.48 1.12–1.95 20 (23) 1.65 0.77–3.54
   3799–4309 g 1796 (21) 137 (25) 1.59 1.20–2.11 27 (31) 2.65 1.27–5.49
   ≥ 4309 g 428 (5) 37 (7) 1.82 1.22–2.73 5 (6) 1.96 0.66–5.78
   missing 40 (0) 5 (1)    0 (0)   
Size for gestational age*        
   small 271 (3) 20 (4) 1.23 0.77–1.97 2 (2) 0.78 0.19–3.22
   average 5708 (72) 343 (67) ref. 54 (65) ref.
   large 1905 (24) 151 (29) 1.30 1.07–1.59 27 (33) 1.51 0.95–2.40
   missing 314 (4) 27 (5)    1 (1)   
Gestational age category*        
   <37 weeks 657 (8) 43 (8) 1.00 0.72–1.38 4 (5) 0.56 0.20–1.53
   37–42 weeks 6938 (88) 446 (86) ref. 1 (1) ref.
   >42 weeks 311 (4) 28 (5) 1.47 0.98–2.19 2 (2) 0.59 0.14–2.43
   missing 292 (4) 24 (4)    1 (1)   
One minute Apgar score +        
   0–7 1798 (23) 144 (29) 1.32 1.08–1.61 26 (33) 1.62 1.01–2.60
   >7 5884 (77) 359 (71) ref. 53 (67) ref.
   missing 336 (4) 34 (6)    4 (5)   
Five minute Apgar score +        
   0–7 275 (4) 14 (3) 0.77 0.44–1.33 4 (5) 1.47 0.53–4.08
   >7 7394 (96) 488 (97) ref. 75 (95) ref.
   missing 349 (4) 35 (7)    4 (5)   
Assisted ventilation category        
   any 79 (2) 5 (2) 0.93 0.37–2.34 0 (0) ND
   none 4548 (98) 300 (98) ref. 41 (100)   
   missing 356 (7) 31 (9)    6 (13)   
Congenital abnormality        
   any 122 (1) 10 (2) 1.30 0.68–2.51 1 (1) ND
   none 8100 (99) 505 (98) ref. 81 (99)   
   missing 528 (6) 45 (8)    5 (6)   
  1. *collected 1980–2004.
  2. +collected 1981–2004.
  3. collected 1989–2004.
  4. ND = not determined