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Table 3 Birth year adjusted analyses of maternal reproductive characteristics, pregnancy history, and labor and delivery variables and childhood leukemia.

From: Parental and infant characteristics and childhood leukemia in Minnesota

 

Sub-cohort

ALL

AML

 

No. (%)

No. (%)

HR

95% CI

No. (%)

HR

95% CI

Plurality

       

   1

8526 (97)

547 (98)

ref.

86 (99)

ND**

   ≥2

224 (3)

12 (2)

0.82

0.46–1.48

1 (1)

  

   missing

1 (0)

1 (0)

  

0 (0)

  

Previous live births

       

   0

3449 (40)

202 (37)

ref.

29 (33)

ref.

 

   1–2

4251 (49)

286 (52)

1.15

0.95–1.38

49 (56)

1.39

0.87–2.20

   ≥3

903 (11)

61 (11)

1.14

0.85–1.54

9 (10)

1.20

0.56–2.54

   missing

147 (2)

11 (2)

  

0 (0)

  

Prior fetal loss

       

   any

1866 (22)

134 (25)

1.14

0.94–1.41

19 (22)

1.00

0.59–1.68

   none

6711 (78)

407 (75)

ref.

68 (78)

 

ref.

   missing

173 (3)

19 (3)

  

0 (0)

  

Last fetal death interval

       

   no fetal deaths

6564 (80)

404 (77)

ref.

67 (82)

 

ref.

   <3 years

891 (11)

73 (14)

1.30

1.00–1.69

8 (10)

0.92

0.44–1.93

   ≥3 years

722 (9)

51 (10)

1.13

0.83–1.53

7 (8)

0.96

0.44–2.11

   missing

573 (7)

32 (6)

  

5 (6)

  

Last live birth interval

       

   no live births

3449 (40)

202 (37)

ref.

29 (35)

ref.

 

   <3 years

3333 (39)

200 (36)

1.02

0.84–1.25

34 (40)

1.22

0.74–2.02

   ≥3 years

1786 (21)

148 (27)

1.40

1.12–1.75

21 (25)

1.40

0.79–2.47

   missing

182 (2)

10 (2)

  

3 (3)

  

Maternal diabetes*

       

   any

110 (3)

8 (3)

1.00

0.48–2.08

0 (0)

 

ND

   none

3194 (97)

229 (97)

ref.

33 (100)

  

   missing

215 (6)

9 (4)

     

Gestational anemia

       

   yes

80 (2)

8 (3)

1.52

0.72–3.19

1 (2)

 

ND

   no

4612 (98)

305 (97)

ref.

42 (98)

  

   missing

291 (6)

23 (7)

  

4 (9)

  

Maternal hypertension

       

   any

337 (4)

28 (6)

1.32

0.88–1.96

5 (6)

1.40

0.56–3.49

   none

7678 (96)

481 (94)

ref.

76 (94)

 

ref.

   missing

735 (8)

51 (9)

  

6 (7)

  

Intrauterine procedures

       

   yes

203 (2)

13 (2)

1.01

0.57–1.78

2 (2)

0.97

0.24–4.00

   no

8181 (98)

515 (92)

ref.

81 (98)

 

ref.

   missing

366 (4)

32 (6)

  

4 (5)

  

Maternal weight gain +

       

   < 30 lbs

2323 (60)

148 (56)

ref.

12 (36)

 

ref.

   ≥ 30 lbs

1526 (40)

115 (44)

1.17

0.91–1.52

21 (64)

2.59

1.27–5.31

   missing

1134 (23)

73 (22)

  

14 (30)

  

Prenatal care index

       

   less than adequate

2300 (33)

146 (31)

0.95

0.77–1.16

16 (22)

0.57

0.33–1.00

   adequate

4747 (67)

323 (69)

ref.

57 (78)

 

ref.

   missing

1151 (14)

72 (13)

  

11 (13)

  

Induction of labor

       

   yes

1432 (27)

92 (27)

0.97

0.75–1.24

18 (39)

1.67

0.91–3.04

   no

3878 (73)

244 (73)

ref.

28 (61)

 

ref.

   missing

225 (4)

19 (5)

  

4 (8)

  

Type of delivery

       

   vaginal

6952 82)

432 (82)

ref.

73 (86)

 

ref.

   caesarean section

1485 (18)

98 (18)

1.03

0.82–1.30

12 (14)

0.75

0.41–1.39

   missing

313 (4)

30 (5)

  

2 (2)

  
  1. *collected 1992–2004.
  2. +collected 1989–2004.
  3. collected 1980–2004.
  4. collected 1976–1979, 1989–2004.
  5. **ND = not determined