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Table 2 Study Schedule

From: Design of a randomised controlled trial on immune effects of acidic and neutral oligosaccharides in the nutrition of preterm infants: carrot study

 

< 48 h

Day 4

day 7

day 14

day 30

5 months

1 year

2 year

Immune response

        

Response to immunizations

     

x

x

 

Cytokine response

x

 

x

x

 

x

x

 

Faecal Calprotectin/IL-8

x

 

x

x

x

x

x

 

Postnatal adaptation of the gut

        

Intestinal permeability

x

x

x

     

Intestinal microflora

x

 

x

x

x

x

x

 

Intestinal viscosity

    

x

x

x

 

Long-term outcome

        

IgE/IgG4

x

    

x

x

 

Allergic and infectious diseases

      

x

 

Side effects immunizations†

        

Neurodevelopment

      

x

x

  1. †Standardized questionnaires (Preparedness and Response Unit, Centre for Infectious disease Control Netherlands, National Institute for Public Health and the Environment, The Netherlands) after the 1st, 2nd, 3rd and 4th immunization.