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Table 2 Study Schedule

From: Design of a randomised controlled trial on immune effects of acidic and neutral oligosaccharides in the nutrition of preterm infants: carrot study

  < 48 h Day 4 day 7 day 14 day 30 5 months 1 year 2 year
Immune response         
Response to immunizations       x x  
Cytokine response x   x x   x x  
Faecal Calprotectin/IL-8 x   x x x x x  
Postnatal adaptation of the gut         
Intestinal permeability x x x      
Intestinal microflora x   x x x x x  
Intestinal viscosity      x x x  
Long-term outcome         
IgE/IgG4 x      x x  
Allergic and infectious diseases        x  
Side effects immunizations         
Neurodevelopment        x x
  1. Standardized questionnaires (Preparedness and Response Unit, Centre for Infectious disease Control Netherlands, National Institute for Public Health and the Environment, The Netherlands) after the 1st, 2nd, 3rd and 4th immunization.