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Table 1 Hypothyroxinaemia in preterm infants is linked with poor neurodevelopmental outcome

From: TIPIT: A randomised controlled trial of thyroxine in preterm infants under 28 weeks gestation: Magnetic Resonance Imaging and Magnetic Resonance Angiography protocol

Study Participants Outcome
Reuss et al [57] 463 infants born below 33 weeks' gestation 4-fold increased risk of disabling cerebral palsy at 2 years of age associated with hypothyroxinaemia
Den Ouden et al [58] 563 infants born below 32 weeks' gestation Higher incidence of neurological dysfunction at 5 and 9 years of age associated with hypothyroxinaemia
Leviton et al [36] 1414 infants weighing 500 to 1500 g Double the risk of cerebral white matter changes associated with hypothyroxinaemia
Paul et al [59] 343 infants weighing less than 1500 grams Increased mortality and incidence of intraventricular haemorrhage associated with hypothyroxinaemia
Lucas et al [60] 279 infants born below 36 weeks' gestation Reduction in IQ at 8 years of age associated with low T3
Meijer et al[61] 563 infants born below 32 weeks' gestation and/or birthweight less than 1500 g Negative score on the three milestones of development at 2 years of age associated with hypothyroxinaemia