Study | Participants | Outcome |
---|---|---|
Reuss et al [57] | 463 infants born below 33 weeks' gestation | 4-fold increased risk of disabling cerebral palsy at 2 years of age associated with hypothyroxinaemia |
Den Ouden et al [58] | 563 infants born below 32 weeks' gestation | Higher incidence of neurological dysfunction at 5 and 9 years of age associated with hypothyroxinaemia |
Leviton et al [36] | 1414 infants weighing 500 to 1500 g | Double the risk of cerebral white matter changes associated with hypothyroxinaemia |
Paul et al [59] | 343 infants weighing less than 1500 grams | Increased mortality and incidence of intraventricular haemorrhage associated with hypothyroxinaemia |
Lucas et al [60] | 279 infants born below 36 weeks' gestation | Reduction in IQ at 8 years of age associated with low T3 |
Meijer et al[61] | 563 infants born below 32 weeks' gestation and/or birthweight less than 1500 g | Negative score on the three milestones of development at 2 years of age associated with hypothyroxinaemia |