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Table 1 Hypothyroxinaemia in preterm infants is linked with poor neurodevelopmental outcome

From: TIPIT: A randomised controlled trial of thyroxine in preterm infants under 28 weeks gestation: Magnetic Resonance Imaging and Magnetic Resonance Angiography protocol

Study

Participants

Outcome

Reuss et al [57]

463 infants born below 33 weeks' gestation

4-fold increased risk of disabling cerebral palsy at 2 years of age associated with hypothyroxinaemia

Den Ouden et al [58]

563 infants born below 32 weeks' gestation

Higher incidence of neurological dysfunction at 5 and 9 years of age associated with hypothyroxinaemia

Leviton et al [36]

1414 infants weighing 500 to 1500 g

Double the risk of cerebral white matter changes associated with hypothyroxinaemia

Paul et al [59]

343 infants weighing less than 1500 grams

Increased mortality and incidence of intraventricular haemorrhage associated with hypothyroxinaemia

Lucas et al [60]

279 infants born below 36 weeks' gestation

Reduction in IQ at 8 years of age associated with low T3

Meijer et al[61]

563 infants born below 32 weeks' gestation and/or birthweight less than 1500 g

Negative score on the three milestones of development at 2 years of age associated with hypothyroxinaemia