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Table 5 Diagnostic work up in correctly (CR) and not correctly referred (NCR) children > 3 years old.

From: The diagnostic work up of growth failure in secondary health care; An evaluation of consensus guidelines

   University hospital General hospital Difference in categories between 2 hospitals (p-value)
   CR (n = 284) (%) NCR (n = 63) (%) CR (n = 85) (%) NCR (n = 24) (%)  
Routine laboratory investigations       
Anemia/infections   0.4/39.8 0.0/25.4 1.2/57.6 4.2/37.5 < 0.01
Liver diseases   22.5/4.2 2.8/0.0 14.1/21.2 8.3/25.0 0.03
Renal diseases (blood)   1.4/27.3 0.0/17.5 0.0/38.8 0.0/33.3 0.5
Celiac disease   21.1/15.8 11.1/3.2 49.4/4.7 25.0/4.2 < 0.01
Hypothyroidism   37.0/3.2 2.5/0.0 45.9/3.5 29.2/8.3 0.02
Growth hormone deficiency   35.2 9.5 45.9 25 0.02
Turner syndrome *   17.2 6.5 14.0 18.1 1.0
Renal diseases (urine)   0.0/19.4 0.0/19.0 0.0/40.0 0.0/29.2 < 0.01
Combined categories (at least one test category)   4.9/52.1 1.6/39.7 18.8/49.4 33.3/16.7 < 0.01
Further and specific diagnostics       
Special investigations Chromosomal analyses for Turner syndrome* 26.2 6.5 26.0 0.0 0.9
  Biopsy** 2.1 0.0 5.9 0.0 0.03
  Zinc-determination 0.4 0.0 0.0 0.0 0.6
Further, more specific tests GH-tests 16.2 3.2 12.9 0.0 0.3
  Other tests*** 8.8 3.2 28.2 25.0 < 0.01
  1. Percentages of patients with Complete (all elements)/partial (at least one element) evaluation are given (several test categories per patient).
  2. CR = Correctly referred; NCR = Not correctly referred
  3. * These categories are only applicable to girls. The percentages are therefore calculated only on the female population.
  4. **biopsy to rule out celiac disease.
  5. *** other tests, like stool examinations, X-rays of the skeleton, ultrasounds of abdomen, hart, kidneys and thyroids, serum levels of steroids, genetic analyses, immunologic tests and allergic tests