Table 6 Adverse events recorded during TB treatment according to the type of event, likely cause and relation to TB treatment and/or HAART
Type of adverse event | Likely cause | Relation to TB Rx | Relation to HAART | TB Rx regimen | TB Rx change | HAART outcome | Clinical outcome |
|---|---|---|---|---|---|---|---|
Raised liver enzymes n = 8 | |||||||
Transaminitis (severe*) | Auto-immune haemolysis | 6 weeks | No HAART | HRZE | Alternative Rx 3 months | N/A | Resolved |
All enzymes (severe*) | Uncertain | 5 months | 1 month before TB Rx | HRZEO | Stopped | Suspended 2 months | Resolved |
Raised ALT (severe*) | TB drugs | 2 months | >2 months after TB Rx | HRZE | Unchanged | Unchanged | Resolved |
All enzymes (moderate*) | TB drugs (PZA) | 1 week | No HAART | HRZE | Alternative Rx 6 months | N/A | Resolved |
Transaminitis (severe*) | TB drugs (PZA) | 1 week | 1 month before TB Rx | HRZE | Alternative Rx 3 months | Suspended 1 week | Resolved |
Raised canalicular enzymes (severe*) | Uncertain | 4 months | >2 months after TB Rx | HRZ | Alternative Rx 2 months | Unchanged | Resolved |
All enzymes (mild*) | CMV disease | 2 months | None | HRZEth | Alternative Rx 1 month | N/A | Died |
Transaminitis (severe*) | Klebsiella sepsis | 3 weeks | 1 month after TB Rx | HRZE | Alternative Rx 1 day | Suspended | Died |
Skin reaction n = 4 | |||||||
Urticarial | PZA | 1 day | None | HRZE | PZA stopped | N/A | Resolved |
Mild unspecified | Uncertain | 9 months | >2 months after TB | HZEEthAT | Unchanged | Unchanged | Resolved |
Urticarial | Possibly PZA | 1 day | None | HRZ | Alternative Rx 2 months | N/A | Resolved |
Urticarial | Uncertain | 2 months | <2 months after TB | HRZ | Alternative Rx 1 month | Suspended 1 month | Resolved |
Bone marrow suppression n = 1 | |||||||
Anaemia and low platelets | Sepsis | 3 weeks | None | HRZEth | Suspended | N/A | Died |