Table 6 Performance of procalcitonin at birth, at 12–24 h, and 36–48 h of life for the diagnosis of neonatal sepsis of vertical transmission (cutoff points selected to achieve 90% sensitivity).
From: Evaluation of procalcitonin for diagnosis of neonatal sepsis of vertical transmission
At birth n = 205 | 12–24 h of life n = 212 | 36–48 h of life n = 193 | |
|---|---|---|---|
Cutoff, ng/ml | ≥0.15 | ≥1.2 | ≥0.75 |
Sensitivity, % (95% CI) | 91.2 (81.1 – 96.2) | 90.2 (80.2 – 95.4) | 91.8 (80.8 – 96.8%) |
Specificity (95% CI) | 10.8 (6.8 – 16.8) | 43.0 (35.4 – 51.0) | 51.4 (43.3 – 59.4) |
Youden's index | 0.02 | 0.33 | 0.43 |
PPV (95% CI) | 28.3 (22.3 – 35.2) | 39.0 (31.3 – 47.2) | 55.9 (44.1 – 67.1) |
NPV (95% CI) | 76.2 (54.9 – 89.4) | 91.5 (82.8 – 96.1) | 91.2 (84.9 – 95.0) |
LR+ (95% CI) | 1.02 (0.93 – 1.13) | 1.58 (1.35 – 1.86) | 1.89 (1.57 – 2.28) |
LR- (95% CI) | 0.81 (0.32 – 2.07) | 0.23 (0.10–0.50) | 0.16 (0.06 – 0.41) |