From: Evaluation of procalcitonin for diagnosis of neonatal sepsis of vertical transmission
At birth n = 205 | 12–24 h of life n = 212 | 36–48 h of life n = 193 | |
---|---|---|---|
Cutoff, ng/ml | ≥0.55 | ≥4.7 | ≥1.7 |
Sensitivity, % (95% CI) | 75.4 (62.9 – 84.8) | 73.8 (61.6 – 83.2) | 77.6 (64.1 – 87.0%) |
Specificity (95% CI) | 72.3 (64.6 – 78.9) | 80.8 (73.8 – 86.3) | 79.2 (71.8 – 85.0) |
Youden's index | 0.48 | 0.55 | 0.57 |
PPV (95% CI) | 51.2 (40.7 – 61.6) | 60.8 (49.4 – 71.1) | 55.9 (44.1 – 67.1) |
NPV (95% CI) | 88.4 (81.5 – 93.0) | 88.4 (82.0 – 92.7) | 91.2 (84.9 – 95.0) |
LR+ (95% CI) | 2.72 (2.02 – 3.67) | 3.84 (2.68 – 5.50) | 3.72 (2.62 – 5.29) |
LR- (95% CI) | 0.34 (0.21 – 0.55) | 0.32 (0.21–0.50) | 0.28 (0.17 – 0.48) |