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Table 5 Analysis of adverse effects of therapeutic hypothermia

From: A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy – are we there yet?

Number of included trials Number of participants Adverse event Relative risk (95% CI)
4 [10,11,21,25] 526 Sinus bradycardia 7.42 (2.52, 21.87)
Number needed to harm: 13 (95% CI: 8, 20)
3 [10,11,21] 464 Arrhythmia requiring treatment 1.04 (0.07, 16.39)
4 [10,11,21,24] 483 Hypotension 1.17 (0.96, 1.42)
3 [10,21,25] 318 Thrombocytopenia 1.47 (1.07, 2.03)
Number needed to harm: 8 (95% CI: 5, 50)
3 [10,11,25] 500 Coagulopathy 1.28 (0.94, 1.75)
2 [10,25] 292 Anemia 1.75 (0.86, 3.57)
3 [10,11,21] 464 Hypoglycemia 0.76 (0.49 to 1.17)
5 [10,11,21,24,25] 545 Abnormal renal function 0.91 (0.79 to 1.05)
2 [10,11] 448 Hepatic dysfunction 0.83 (0.64, 1.09)
4 [10,11,21,25] 526 Sepsis 1.04 (0.45 to 2.39)
5 [10,11,21,24,25] 545 Seizures 1.04 (0.91 to 1.18)
2 [10,25] 292 Hypokalemia 1.02 (0.84 to 1.25)