Selective head cooling | Whole body cooling | ||||
---|---|---|---|---|---|
Gunn 1998 | Gluckman 2005 | Shankaran 2002 | Shankaran 2005 | Eicher 2005 | |
Definition of asphyxia | 5 min Apgar < 7 or pH < 7,1 (first hour) | 10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 16 mmol (first hour) | pH < 7.0 or BD > 16 or (if no blood gas or pH 7.01–7.15 or BD# 10–15 mmol: acute perinatal event and seizures or HIE*) | 10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 16 or (if no blood gas or pH 7.01–7.15 or BD# 10–15 mmol: acute perinatal event and seizures or HIE*) | 10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 13 or acute perinatal event |
Definition of HIE* | Sarnat stage 2–3 | Pre-randomisation EEG and Sarnat stage 2–3 | Modified Sarnat stage 2–3 | Modified Sarnat stage 2–3 | Sarnat stage 1–3 |