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Table 2 Inclusion criteria of included trials

From: A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy – are we there yet?

  Selective head cooling Whole body cooling
  Gunn 1998 Gluckman 2005 Shankaran 2002 Shankaran 2005 Eicher 2005
Definition of asphyxia 5 min Apgar < 7 or pH < 7,1 (first hour) 10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 16 mmol (first hour) pH < 7.0 or BD > 16 or (if no blood gas or pH 7.01–7.15 or BD# 10–15 mmol: acute perinatal event and seizures or HIE*) 10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 16 or (if no blood gas or pH 7.01–7.15 or BD# 10–15 mmol: acute perinatal event and seizures or HIE*) 10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 13 or acute perinatal event
Definition of HIE* Sarnat stage 2–3 Pre-randomisation EEG and Sarnat stage 2–3 Modified Sarnat stage 2–3 Modified Sarnat stage 2–3 Sarnat stage 1–3
  1. #BD base deficit * Hypoxic ischemic encephalopathy