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Table 3 Mortality: Cox proportional hazards models between baseline characteristics and death

From: Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa

  

Univariate analysis

Multivariate analysis

Baseline Characteristic

No. of Deaths

Hazard ratio 95% CI

p

Hazard ratio 95% CI

p

Gender

     

   Male

6

1.00

 

1.00

-

   Female

7

1.14 (0.38–3.40)

0.810

2.78 (0.66–11.86)

0.163

Age

     

   < 3 yrs

5

1.00

 

1.00

-

   3–5 yrs

2

0.35 (0.07–1.81)

0.210

1.37 (0.21–9.04)

0.747

   6–8 yrs

3

0.52 (0.12–2.16)

0.365

0.25 (0.02–2.93)

0.268

   ≥ 9 yrs

3

0.92 (0.22–3.85)

0.908

2.18 (0.44–10.85)

0.342

WHO clinical stage

     

   Stage 1–3

7

1.00

 

1.00

-

   Stage 4

6

3.01 (1.01–8.95)

0.048*

1.82 (0.41–8.03)

0.430

Weight (**2 missing values)

     

   ≥ 5 Percentile

1

1.00

 

1.00

-

   < 5 Percentile

10

8.60 (1.10–67.15)

0.040*

4.96 (0.45–55.31)

0.193

CD4% (**1 missing value)

     

   ≥ 5%

5

1.00

 

-

-

   < 5%

7

2.65 (0.84–8.34)

0.097

-

-

Tuberculosis

     

   Absent

5

1.00

 

1.00

-

   Present

8

3.39 (1.11–10.37)

0.032*

1.08 (0.25–4.59)

0.919

Pulmonary

     

   Absent

9

1.00

 

-

-

   Present

4

1.53 (0.47–5.01)

0.480

-

-

Extrapulmonary

     

   Absent

10

1.00

 

-

-

   Present

3

3.06 (0.84–11.20)

0.091

-

-

Chronic gastroenteritis

     

   Absent

3

1.00

 

1.00

-

   Present

10

6.69 (1.84–24.30)

0.004*

12.34 (1.27–119.71)

0.030*

Pneumonia

     

   Absent

9

1.00

 

1.00

-

   Present

4

5.23 (1.61–16.98)

0.006*

4.03 (0.79–20.54)

0.094

PCP

     

   Absent

10

1.00

 

1.00

-

   Present

3

3.81(1.05–13.86)

0.042*

5.35 (0.84–33.86)

0.075

Oesophageal candidiasis

     

   Absent

12

1.00

 

-

-

   Present

1

0.92 (0.12–7.04)

0.932

-

-

Hemoglobin

     

   > 10 g/dl

5

1.00

 

-

-

   ≤ 10 g/dl

8

1.87 (0.61–5.73)

0.272

-

-

Primary caregiver HIV Status

     

   HIV negative or unknown

10

1.00

-

1.00

-

   HIV positive

3

0.26 (0.07–0.95)

0.041*

0.12 (0.02–0.88)

0.037*

Primary caregiver receiving HAART at Sinikithemba

     

   Primary caregiver not in care

12

1.00

-

-

-

   Primary caregiver in care

1

0.13 (0.02–1.01)

0.051

-

-

Parent status

     

   Two parent alive

6

1.00

-

-

-

   One parent alive

4

0.92 (0.26–3.26)

0.896

-

-

   Neither parent living

3

0.82 (0.21–3.28)

0.778

-

-